Improving Oral Cavity Cancer Diagnosis and Treatment With Fluorescence Molecular Imaging

Floris Voskuil, Jasper Vonk, Jaron Wit, de, Max Witjes*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)
109 Downloads (Pure)


Early diagnosis and radical surgical excision of oral squamous cell carcinomas are essential for achieving optimal treatment outcomes. To date, diagnostic tools that rely on anatomical anomalies provide limited information and resolution in clinical practice. As a result, oral cancer is often detected in an advanced stage. Also, no reliable real-time intraoperative tools are readily available for the evaluation of surgical resection margins. Fluorescence imaging visualises biological processes that occur in early carcinogenesis and could, therefore, enable detection of small tumours in early stages. Furthermore, due to the high sensitivity and spatial resolution, fluorescence imaging could assist in resection margin assessment during surgery. In this review, we discuss several techniques that employ fluorescence for early diagnosis and surgical guidance in oral squamous cell carcinoma and present future perspectives on the potential of fluorescence imaging in oral cancer in the near future.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalOral diseases
Issue number1
Publication statusPublished - Jan-2021


  • early diagnosis
  • fluorescence imaging
  • fluorescence-guided surgery
  • molecular imaging
  • oral squamous cell carcinoma
  • surgical resection margin evaluation


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