Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications

Baojie Zhang, Deng Chen, Frank Dekker, Wim J. Quax*

*Corresponding author for this work

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Epigenetic regulation refers to alterations to the chromatin template that collectively establish differential patterns
of gene transcription. Post-translational modifications of the histones play a key role in epigenetic regulation of
gene transcription. In this review, we provide an overview of recent studies on the role of histone modifications
in carcinogenesis. Since tumour-selective ligands such as tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL) are well-considered as promising anti-tumour therapies, we summarise strategies for improving
TRAIL sensitivity by inhibiting aberrant histone modifications in cancers. In this perspective we also discuss new
epigenetic drug targets for enhancing TRAIL-mediated apoptosis.
Original languageEnglish
Article numberCDR 2020-58
Pages (from-to)1-13
Number of pages13
JournalCancer Drug Resistance
Issue number3
Publication statusPublished - 9-Oct-2020

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