Impulsive aggression and response inhibition in attention-deficit/hyperactivity disorder and disruptive behavioral disorders: Findings from a systematic review

Andrei A. Puiu*, Olga Wudarczyk, Katharina S. Goerlich, Mikhail Votinov, Beate Herpertz-Dahlmann, Bruce Turetsky, Kerstin Konrad

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    37 Citations (Scopus)
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    Abstract

    Background: Although impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms.

    Aims and Methods: Here, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder -specific and shared IA and RI aberrant neural mechanisms.

    Results: In ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA. Structural alterations were most pronounced in the cingulate cortex. Subjects with DBDs showed marked cortico-subcortical dysfunctions. ADHD and DBDs share similar cortico-limbic structural and functional alterations. RI deficits in ADHD highlighted hypoactivity in the dorso/ventro-lateral PFC, insula, and striatum, while the paralimbic system was primarily dysfunctional in DBDs. Across disorders, extensively altered cortico-limbic dysfunctions underlie IA, while RI was mostly associated with aberrant prefrontal activity.

    Conclusion: Control network deficits were evidenced across clinical phenotypes in IA and RI. Dysfunctions at any level within these cortico-subcortical projections lead to deficient cognitive-affective control by ascribing emotional salience to otherwise irrelevant stimuli. The clinical implications of these findings are discussed.

    Original languageEnglish
    Pages (from-to)231-246
    Number of pages16
    JournalNeuroscience and Biobehavioral Reviews
    Volume90
    DOIs
    Publication statusPublished - Jul-2018

    Keywords

    • Impulsive aggression
    • Response inhibition
    • ADHD
    • DBDs
    • fMRI
    • sMRI
    • Prefrontal cortex
    • Cingulate cortex
    • Paralimbic system
    • Control
    • Top-Down
    • Emotional salience
    • DEFICIT-HYPERACTIVITY DISORDER
    • INTERMITTENT EXPLOSIVE DISORDER
    • OPPOSITIONAL DEFIANT DISORDER
    • STOP-SIGNAL TASK
    • MEDIAL PREFRONTAL CORTEX
    • ONSET CONDUCT DISORDER
    • FRONTO-STRIATAL UNDERACTIVATION
    • RIGHT TEMPOROPARIETAL JUNCTION
    • BRAIN STRUCTURE ABNORMALITIES
    • CALLOUS-UNEMOTIONAL TRAITS

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