TY - JOUR
T1 - In Normal Controls, Both Age and Gender Affect Coagulability as Measured by Thrombelastography
AU - Roeloffzen, Wilfried W. H.
AU - Kluin-Nelemans, Hanneke C.
AU - Mulder, Andre B.
AU - Veeger, Nic J. G. M.
AU - Bosman, Lotte
AU - de Wolf, Joost Th. M.
N1 - Article
PY - 2010/4
Y1 - 2010/4
N2 - BACKGROUND: Our objective was to analyze the effects of age, gender, and the use of oral contraceptives (OCs) on coagulation using thrombelastography (TEG (R)), a single test to analyze both plasma coagulation factors and cellular elements in whole blood.METHODS: TEG (R) variables were measured in native whole blood and in recalcified citrated blood from 120 healthy adults (60 men and 60 women) with various ages and in an additional 29 healthy women using OCs.RESULTS: We observed hypercoagulability in women compared with men and in women using OCs compared with age-matched nonusers. Moreover, we found hypercoagulability with aging. Using the method of Bland and Altman (Lancet 1986;1:307-10), we demonstrated no correlation between TEG (R) measurements in native and recalcified citrated blood.CONCLUSIONS: Aging, female gender, use of OCs, and low-normal hematocrit levels have significant procoagulant effects. TEG measurements in native and recalcified citrated blood are not interchangeable, as indicated by differences between the 2 measurements ranging from 20% in maximal amplitude to 246% in clotting time. Furthermore, the limits of agreement strongly exceeded clinical acceptability to conclude interchangeability. (Anesth Analg 2010;110:987-94)
AB - BACKGROUND: Our objective was to analyze the effects of age, gender, and the use of oral contraceptives (OCs) on coagulation using thrombelastography (TEG (R)), a single test to analyze both plasma coagulation factors and cellular elements in whole blood.METHODS: TEG (R) variables were measured in native whole blood and in recalcified citrated blood from 120 healthy adults (60 men and 60 women) with various ages and in an additional 29 healthy women using OCs.RESULTS: We observed hypercoagulability in women compared with men and in women using OCs compared with age-matched nonusers. Moreover, we found hypercoagulability with aging. Using the method of Bland and Altman (Lancet 1986;1:307-10), we demonstrated no correlation between TEG (R) measurements in native and recalcified citrated blood.CONCLUSIONS: Aging, female gender, use of OCs, and low-normal hematocrit levels have significant procoagulant effects. TEG measurements in native and recalcified citrated blood are not interchangeable, as indicated by differences between the 2 measurements ranging from 20% in maximal amplitude to 246% in clotting time. Furthermore, the limits of agreement strongly exceeded clinical acceptability to conclude interchangeability. (Anesth Analg 2010;110:987-94)
KW - THROMBIN GENERATION
KW - BLOOD-COAGULATION
KW - CITRATE STORAGE
KW - THROMBOELASTOGRAPHY
KW - HYPERCOAGULABILITY
U2 - 10.1213/ANE.0b013e3181d31e91
DO - 10.1213/ANE.0b013e3181d31e91
M3 - Article
SN - 0003-2999
VL - 110
SP - 987
EP - 994
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 4
ER -