In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

Annemiek M. Roescher; Albertus Timmer; Michelle E. van der Laan; Jan Jaap H. M. Erwich; Arend F. Bos; Elisabeth M. W. Kooi; Elise A. Verhagen

doi:10.1038/pr.2015.20

In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

Annemiek M. Roescher^*, Albertus Timmer, Michelle E. van der Laan, Jan Jaap H. M. Erwich, Arend F. Bos, Elisabeth M. W. Kooi, Elise A. Verhagen

^*Corresponding author for this work

Reproductive Origins of Adult Health and Disease (ROAHD)

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.

METHOD: In a prospective, observational study of 42 preterm infants (gestational age

RESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (P

CONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.

Original language	English
Pages (from-to)	688-695
Number of pages	8
Journal	Pediatric Research
Volume	77
Issue number	5
DOIs	https://doi.org/10.1038/pr.2015.20
Publication status	Published - May-2015

Keywords

PLACENTAL REACTION PATTERNS
INTRAVENTRICULAR HEMORRHAGE
HISTOLOGIC CHARACTERISTICS
NEUROLOGIC IMPAIRMENT
LESIONS
BIRTH
CHORIOAMNIONITIS
REPRODUCIBILITY
NOSOLOGY
PALSY

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title = "In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction",

abstract = "BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.METHOD: In a prospective, observational study of 42 preterm infants (gestational ageRESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (PCONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.",

keywords = "PLACENTAL REACTION PATTERNS, INTRAVENTRICULAR HEMORRHAGE, HISTOLOGIC CHARACTERISTICS, NEUROLOGIC IMPAIRMENT, LESIONS, BIRTH, CHORIOAMNIONITIS, REPRODUCIBILITY, NOSOLOGY, PALSY",

author = "Roescher, {Annemiek M.} and Albertus Timmer and {van der Laan}, {Michelle E.} and Erwich, {Jan Jaap H. M.} and Bos, {Arend F.} and Kooi, {Elisabeth M. W.} and Verhagen, {Elise A.}",

year = "2015",

month = may,

doi = "10.1038/pr.2015.20",

language = "English",

volume = "77",

pages = "688--695",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Nature Publishing Group",

number = "5",

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TY - JOUR

T1 - In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

AU - Roescher, Annemiek M.

AU - Timmer, Albertus

AU - van der Laan, Michelle E.

AU - Erwich, Jan Jaap H. M.

AU - Bos, Arend F.

AU - Kooi, Elisabeth M. W.

AU - Verhagen, Elise A.

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.METHOD: In a prospective, observational study of 42 preterm infants (gestational ageRESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (PCONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.

AB - BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.METHOD: In a prospective, observational study of 42 preterm infants (gestational ageRESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (PCONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.

KW - PLACENTAL REACTION PATTERNS

KW - INTRAVENTRICULAR HEMORRHAGE

KW - HISTOLOGIC CHARACTERISTICS

KW - NEUROLOGIC IMPAIRMENT

KW - LESIONS

KW - BIRTH

KW - CHORIOAMNIONITIS

KW - REPRODUCIBILITY

KW - NOSOLOGY

KW - PALSY

U2 - 10.1038/pr.2015.20

DO - 10.1038/pr.2015.20

M3 - Article

C2 - 25665059

SN - 0031-3998

VL - 77

SP - 688

EP - 695

JO - Pediatric Research

JF - Pediatric Research

IS - 5

ER -

In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

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