In silico modelling of the human intestinal microflora

DJ Kamerman*, MHF Wilkinson

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    The ecology of the human intestinal microflora and its interaction with the host are poorly understood. Though more and more data are being acquired, in part using modern molecular methods, development of a quantitative theory has not kept pace with this development. This is in part due to the complexity of the system, and to the lack of simulation environments in which to test what the ecological effect of a hypothetical mechanism of interaction would be, before resorting to laboratory experiments. The MIMICS project attempts to address this through the development of a system for simulation of the intestinal microflora. In this paper the design, possibilities and relevance of this simulator including an intestinal wall are discussed.

    Original languageEnglish
    Title of host publicationCOMPUTATIONAL SCIENCE-ICCS 2002, PT I, PROCEEDINGS
    EditorsP Sloot, CJK Tan, JJ Dongarra, AG Hoekstra
    Place of PublicationBERLIN
    PublisherSpringer
    Pages117-126
    Number of pages10
    ISBN (Print)3-540-43591-3
    Publication statusPublished - 2002
    EventInternational Conference on Computational Science - , Netherlands
    Duration: 21-Apr-200224-Apr-2002

    Publication series

    NameLECTURE NOTES IN COMPUTER SCIENCE
    PublisherSPRINGER-VERLAG BERLIN
    Volume2329
    ISSN (Print)0302-9743

    Other

    OtherInternational Conference on Computational Science
    Country/TerritoryNetherlands
    Period21/04/200224/04/2002

    Keywords

    • ESCHERICHIA-COLI
    • SIMULATION
    • INFECTION
    • DYNAMICS
    • TRACT

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