In vitro analysis of polyurethane foam as a topical hemostatic agent

Ferdinand I. Broekema*, Wim van Oeveren, Johan Zuidema, Susan H. Visscher, Rudolf R. M. Bos

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    23 Citations (Scopus)

    Abstract

    Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study the suitability of different newly developed polyurethane-based foams as a hemostatic agent has been evaluated and compared to commonly used agents. An experimental in vitro test model was used in which human blood flowed through the test material. Different modified polyurethane foams were compared to collagen and gelatin. The best coagulation was achieved with collagen. The results of the polyurethane foam improved significantly by increasing the amount of polyethylene glycol. Therefore, the increase of the PEG concentration seems a promising approach. Additional in vivo studies will have to be implemented to assess the application of polyurethane foam as a topical hemostatic agent.

    Original languageEnglish
    Pages (from-to)1081-1086
    Number of pages6
    JournalJournal of Materials Science-Materials in Medicine
    Volume22
    Issue number4
    DOIs
    Publication statusPublished - Apr-2011

    Keywords

    • THROMBIN TISSUE SEALANT
    • COAGULATION CASCADE
    • PARTIAL NEPHRECTOMY
    • BLOOD-COAGULATION
    • PLATELET-ADHESION
    • BLOCK-COPOLYMERS
    • CROSS-LINKING
    • WHOLE-BLOOD
    • POLYETHYLENE
    • GENERATION

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