In vivo detection of apoptosis in an intracardiac tumor

L Hofstra; E A Dumont; P W Thimister; G A Heidendal; A P DeBruine; T W Elenbaas; H H Boersma; W L van Heerde; C P Reutelingsperger

doi:10.1001/jama.285.14.1841

In vivo detection of apoptosis in an intracardiac tumor

L Hofstra
, E A Dumont
, P W Thimister
, G A Heidendal
, A P DeBruine
, T W Elenbaas
, H H Boersma
, W L van Heerde
, C P Reutelingsperger

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Abstract

We previously demonstrated in vivo imaging of cell death in the myocardia of patients with acute myocardial infarction using technetium Tc 99m–labeled annexin-V (99mTc-p-annexin-V [Apomate], Theseus Imaging, Cambridge, Mass) and nuclear imaging.1 Because high proliferation and apoptotic indices have been reported in rapidly growing malignant tumors,2 information about the extent of apoptosis in the tumor may also provide insight into the tumor's biology and prognosis.

Original language	English
Pages (from-to)	1841-1842
Number of pages	2
Journal	JAMA
Volume	285
Issue number	14
DOIs	https://doi.org/10.1001/jama.285.14.1841
Publication status	Published - 11-Apr-2001

Keywords

Aged
Annexin A5
Apoptosis
Heart Neoplasms
Heart Ventricles
Humans
Immunohistochemistry
Male
Organotechnetium Compounds
Radiopharmaceuticals
Sarcoma
Thallium
Tomography, Emission-Computed
CELL

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In Vivo Detection of Apoptosis in an Intracardiac Tumor
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title = "In vivo detection of apoptosis in an intracardiac tumor",

abstract = "We previously demonstrated in vivo imaging of cell death in the myocardia of patients with acute myocardial infarction using technetium Tc 99m–labeled annexin-V (99mTc-p-annexin-V [Apomate], Theseus Imaging, Cambridge, Mass) and nuclear imaging.1 Because high proliferation and apoptotic indices have been reported in rapidly growing malignant tumors,2 information about the extent of apoptosis in the tumor may also provide insight into the tumor's biology and prognosis.",

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AU - Hofstra, L

AU - Dumont, E A

AU - Thimister, P W

AU - Heidendal, G A

AU - DeBruine, A P

AU - Elenbaas, T W

AU - Boersma, H H

AU - van Heerde, W L

AU - Reutelingsperger, C P

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KW - Aged

KW - Annexin A5

KW - Apoptosis

KW - Heart Neoplasms

KW - Heart Ventricles

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Organotechnetium Compounds

KW - Radiopharmaceuticals

KW - Sarcoma

KW - Thallium

KW - Tomography, Emission-Computed

KW - CELL

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SN - 0098-7484

VL - 285

SP - 1841

EP - 1842

JO - JAMA

JF - JAMA

IS - 14

ER -

In vivo detection of apoptosis in an intracardiac tumor

Abstract

Keywords

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