In Vivo Phosphorus Magnetic Resonance Spectroscopy in Multiple Sclerosis

JM MINDERHOUD; EL MOOYAART; RL KAMMAN; AW Teelken; MC HOOGSTRATEN; LM VENCKEN; E.J. 's Gravenmade; W van den Burg

doi:10.1001/archneur.1992.00530260063021

In Vivo Phosphorus Magnetic Resonance Spectroscopy in Multiple Sclerosis

JM MINDERHOUD^*, EL MOOYAART, RL KAMMAN, AW Teelken, MC HOOGSTRATEN, LM VENCKEN, E.J. 's Gravenmade, W van den Burg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Localized phosphorus magnetic resonance spectroscopy at 1.5 T was performed in 39 patients with multiple sclerosis and in 15 healthy controls. The multiple sclerosis spectra showed increased creatine phosphate levels. This increase was correlated with the severity of the handicap and was greater in patients with a progressive course of the disease than in patients with relapsing-remitting disease. No clear abnormalities were observed in the spectra of patients with multiple sclerosis regarding the phosphomonoesters, phosphodiesters, inorganic phosphate, and beta-adenosine triphosphate or with respect to pH values. There was an increased creatine phosphate level in the spectra in relation to a low metabolic state of the brain.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Archives of Neurology
Volume	49
Issue number	2
DOIs	https://doi.org/10.1001/archneur.1992.00530260063021
Publication status	Published - Feb-1992

Keywords

BRAIN ENERGY-METABOLISM
P-31 NMR-SPECTROSCOPY
CEREBRAL METABOLISM
NEWBORN-INFANTS
MR SPECTROSCOPY
WHITE MATTER
1.5 TESLA
TUMORS

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title = "In Vivo Phosphorus Magnetic Resonance Spectroscopy in Multiple Sclerosis",

abstract = "Localized phosphorus magnetic resonance spectroscopy at 1.5 T was performed in 39 patients with multiple sclerosis and in 15 healthy controls. The multiple sclerosis spectra showed increased creatine phosphate levels. This increase was correlated with the severity of the handicap and was greater in patients with a progressive course of the disease than in patients with relapsing-remitting disease. No clear abnormalities were observed in the spectra of patients with multiple sclerosis regarding the phosphomonoesters, phosphodiesters, inorganic phosphate, and beta-adenosine triphosphate or with respect to pH values. There was an increased creatine phosphate level in the spectra in relation to a low metabolic state of the brain.",

keywords = "BRAIN ENERGY-METABOLISM, P-31 NMR-SPECTROSCOPY, CEREBRAL METABOLISM, NEWBORN-INFANTS, MR SPECTROSCOPY, WHITE MATTER, 1.5 TESLA, TUMORS",

author = "JM MINDERHOUD and EL MOOYAART and RL KAMMAN and AW Teelken and MC HOOGSTRATEN and LM VENCKEN and {'s Gravenmade}, E.J. and {van den Burg}, W",

year = "1992",

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doi = "10.1001/archneur.1992.00530260063021",

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AU - MINDERHOUD, JM

AU - MOOYAART, EL

AU - KAMMAN, RL

AU - Teelken, AW

AU - HOOGSTRATEN, MC

AU - VENCKEN, LM

AU - 's Gravenmade, E.J.

AU - van den Burg, W

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AB - Localized phosphorus magnetic resonance spectroscopy at 1.5 T was performed in 39 patients with multiple sclerosis and in 15 healthy controls. The multiple sclerosis spectra showed increased creatine phosphate levels. This increase was correlated with the severity of the handicap and was greater in patients with a progressive course of the disease than in patients with relapsing-remitting disease. No clear abnormalities were observed in the spectra of patients with multiple sclerosis regarding the phosphomonoesters, phosphodiesters, inorganic phosphate, and beta-adenosine triphosphate or with respect to pH values. There was an increased creatine phosphate level in the spectra in relation to a low metabolic state of the brain.

KW - BRAIN ENERGY-METABOLISM

KW - P-31 NMR-SPECTROSCOPY

KW - CEREBRAL METABOLISM

KW - NEWBORN-INFANTS

KW - MR SPECTROSCOPY

KW - WHITE MATTER

KW - 1.5 TESLA

KW - TUMORS

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DO - 10.1001/archneur.1992.00530260063021

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