In Vivo Quantification of the Retinal Reflectance Spectral Composition in Elderly Subjects before and after Cataract Surgery: Implications for the Non-Visual Effects of Light

Marina C. Gimenez*, Martijn J. Kanis, Domien G. M. Beersma, Bert A. E. van der Pol, Dirk van Norren, Marijke C. M. Gordijn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Light is the signal that entrains the biological clock in humans to the 24-hour external time. Recently, it has been shown that short wavelengths play a key role in this process. In the present study, we describe a procedure to measure, objectively and in a quick way, the spectral composition of the light reaching the retina in vivo. The instruments involved are the foveal reflection analyzer (FRA) and the macular pigment reflectometer (MPR). By making use of these reflectometers, we show quantitatively that in subjects with cataracts, the light input is especially reduced in the short wavelength range. After cataract surgery during which the crystalline lens is replaced by a transparent artificial lens, the transmittance of the short wavelengths (between 420-500 nm) improved on average by a factor of 4. We conclude that this technique holds great promises for the chronobiological field because it allows for quantification of the spectral composition and light levels reaching the retina in vivo.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalJournal of Biological Rhythms
Volume25
Issue number2
DOIs
Publication statusPublished - Apr-2010

Keywords

  • short wavelengths
  • elderly
  • cataract surgery
  • retinal reflectance
  • SHORT-WAVELENGTH LIGHT
  • AGE-RELATED-CHANGES
  • BLUE-LIGHT
  • INTRAOCULAR LENSES
  • MELATONIN SUPPRESSION
  • CIRCADIAN-RHYTHMS
  • SUPRACHIASMATIC NUCLEUS
  • HIGH-SENSITIVITY
  • GANGLION-CELLS
  • OCULAR MEDIA

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