TY - JOUR
T1 - Incorporating therapeutic drug monitoring into the World Health Organization hierarchy of tuberculosis diagnostics
AU - Ghimire, Samiksha
AU - Bolhuis, Mathieu S
AU - Sturkenboom, Marieke G G
AU - Akkerman, Onno W
AU - de Lange, Wiel C M
AU - van der Werf, Tjip S
AU - Alffenaar, Jan-Willem C
PY - 2016/6
Y1 - 2016/6
N2 - Tuberculosis (TB), once considered as a disease of the past generally afflicting poor people, still claims 1.5 million lives annually [1]. Although 86% of patients with drug susceptible TB are cured with established first-line drugs, treatment is often longer than 6 months due to slow response, compliance problems or adverse drug reactions. In addition, emergence of drug-resistant Mycobacterium tuberculosis strains with an unacceptably low treatment success rate of 50% and TB–HIV co-infection have challenged the goals of global TB control and elimination [1]
AB - Tuberculosis (TB), once considered as a disease of the past generally afflicting poor people, still claims 1.5 million lives annually [1]. Although 86% of patients with drug susceptible TB are cured with established first-line drugs, treatment is often longer than 6 months due to slow response, compliance problems or adverse drug reactions. In addition, emergence of drug-resistant Mycobacterium tuberculosis strains with an unacceptably low treatment success rate of 50% and TB–HIV co-infection have challenged the goals of global TB control and elimination [1]
KW - MULTIDRUG-RESISTANT TUBERCULOSIS
KW - CONTROL PROGRAM
U2 - 10.1183/13993003.00040-2016
DO - 10.1183/13993003.00040-2016
M3 - Letter
C2 - 26989104
SN - 0903-1936
VL - 47
SP - 1867
EP - 1869
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 6
ER -