Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Anouk M. La Rose, Anouk G. Groenen, Benedek Halmos, Venetia Bazioti, Martijn G.S. Rutten, Kishore A. Krishnamurthy, Mirjam H. Koster, Niels J. Kloosterhuis, Marieke Smit, Rick Havinga, Gilles Mithieux, Fabienne Rajas, Folkert Kuipers, Maaike H. Oosterveer, Marit Westerterp*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

Original languageEnglish
Article number100872
Number of pages5
JournalMolecular genetics and metabolism reports
Volume31
DOIs
Publication statusPublished - Jun-2022

Keywords

  • Atherosclerosis
  • Glycogen storage disease type 1a
  • Hyperlipidemia

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