Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Anouk M. La Rose; Anouk G. Groenen; Benedek Halmos; Venetia Bazioti; Martijn G.S. Rutten; Kishore A. Krishnamurthy; Mirjam H. Koster; Niels J. Kloosterhuis; Marieke Smit; Rick Havinga; Gilles Mithieux; Fabienne Rajas; Folkert Kuipers; Maaike H. Oosterveer; Marit Westerterp

doi:10.1016/j.ymgmr.2022.100872

Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Anouk M. La Rose
, Anouk G. Groenen
, Benedek Halmos
, Venetia Bazioti
, Martijn G.S. Rutten
, Kishore A. Krishnamurthy
, Mirjam H. Koster
, Niels J. Kloosterhuis
, Marieke Smit
, Rick Havinga
, Gilles Mithieux
, Fabienne Rajas
, Folkert Kuipers
, Maaike H. Oosterveer
, Marit Westerterp^*

^*Corresponding author for this work

Translational Immunology Groningen (TRIGR)

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

104 Downloads (Pure)

Abstract

Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

Original language	English
Article number	100872
Number of pages	5
Journal	Molecular genetics and metabolism reports
Volume	31
DOIs	https://doi.org/10.1016/j.ymgmr.2022.100872
Publication status	Published - 1-Jun-2022

Keywords

Atherosclerosis
Glycogen storage disease type 1a
Hyperlipidemia

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La Rose, A. M., Groenen, A. G., Halmos, B., Bazioti, V., Rutten, M. G. S., Krishnamurthy, K. A., Koster, M. H., Kloosterhuis, N. J., Smit, M., Havinga, R., Mithieux, G., Rajas, F., Kuipers, F., Oosterveer, M. H., & Westerterp, M. (2022). Increased atherosclerosis in a mouse model of glycogen storage disease type 1a. Molecular genetics and metabolism reports, 31, Article 100872. https://doi.org/10.1016/j.ymgmr.2022.100872

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title = "Increased atherosclerosis in a mouse model of glycogen storage disease type 1a",

abstract = "Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.",

keywords = "Atherosclerosis, Glycogen storage disease type 1a, Hyperlipidemia",

author = "\{La Rose\}, \{Anouk M.\} and Groenen, \{Anouk G.\} and Benedek Halmos and Venetia Bazioti and Rutten, \{Martijn G.S.\} and Krishnamurthy, \{Kishore A.\} and Koster, \{Mirjam H.\} and Kloosterhuis, \{Niels J.\} and Marieke Smit and Rick Havinga and Gilles Mithieux and Fabienne Rajas and Folkert Kuipers and Oosterveer, \{Maaike H.\} and Marit Westerterp",

note = "Funding Information: M.H. Oosterveer and M. Westerterp are supported by VIDI grants ( 917.17.373 and 917.15.350 , respectively) from the Netherlands Organization of Scientific Research (NWO) , and Rosalind Franklin Fellowships from the University of Groningen . Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jun,

day = "1",

doi = "10.1016/j.ymgmr.2022.100872",

language = "English",

volume = "31",

journal = "Molecular genetics and metabolism reports",

issn = "2214-4269",

publisher = "ELSEVIER SCIENCE BV",

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La Rose, AM, Groenen, AG, Halmos, B, Bazioti, V, Rutten, MGS, Krishnamurthy, KA, Koster, MH , Kloosterhuis, NJ , Smit, M , Havinga, R, Mithieux, G, Rajas, F, Kuipers, F, Oosterveer, MH & Westerterp, M 2022, 'Increased atherosclerosis in a mouse model of glycogen storage disease type 1a', Molecular genetics and metabolism reports, vol. 31, 100872. https://doi.org/10.1016/j.ymgmr.2022.100872

TY - JOUR

T1 - Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

AU - La Rose, Anouk M.

AU - Groenen, Anouk G.

AU - Halmos, Benedek

AU - Bazioti, Venetia

AU - Rutten, Martijn G.S.

AU - Krishnamurthy, Kishore A.

AU - Koster, Mirjam H.

AU - Kloosterhuis, Niels J.

AU - Smit, Marieke

AU - Havinga, Rick

AU - Mithieux, Gilles

AU - Rajas, Fabienne

AU - Kuipers, Folkert

AU - Oosterveer, Maaike H.

AU - Westerterp, Marit

N1 - Funding Information: M.H. Oosterveer and M. Westerterp are supported by VIDI grants ( 917.17.373 and 917.15.350 , respectively) from the Netherlands Organization of Scientific Research (NWO) , and Rosalind Franklin Fellowships from the University of Groningen . Publisher Copyright: © 2022 The Authors

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

AB - Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

KW - Atherosclerosis

KW - Glycogen storage disease type 1a

KW - Hyperlipidemia

U2 - 10.1016/j.ymgmr.2022.100872

DO - 10.1016/j.ymgmr.2022.100872

M3 - Article

C2 - 35782606

AN - SCOPUS:85128923902

SN - 2214-4269

VL - 31

JO - Molecular genetics and metabolism reports

JF - Molecular genetics and metabolism reports

M1 - 100872

ER -

Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

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