Increased Incidence of T-Cell Malignancies in Patients with Chronic Lymphocytic Leukemia

Goda Choi, Esther C van den Broek, Olga CG Stam, C.J.M. van Noesel, Sanne H. Tonino, Armon P. Kater

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    We present a patient with chemotherapy-refractory Chronic Lymphocytic
    Leukemia (CLL) in whom postmortem examination showed hepatosplenomegaly,
    with both multiple small-cellular CLL lesions and large-cellular, monoclonal
    T-cell infiltrates. Following this case, the co-incidence of T-cell malignancies and
    CLL was studied using Dutch and American cancer registry databases. Analysis
    showed an excess risk for T-cell malignancies in CLL patients, with increased
    standardized incidence ratios compared with the general population and all
    cancer survivors in the databases. We hypothesize that CLL cells interact with
    T-cells in the microenvironment, facilitating malignant transformation
    Original languageEnglish
    Article number1023
    Number of pages2
    JournalAnnals of Hematology & Oncology
    Issue number2
    Publication statusPublished - 19-Jan-2015


    • Chronic lymphocytic leukemia
    • T-cell lymphoma
    • Neoplastic cell transformation
    • Cohort studies

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