Increased large VLDL particles confer elevated cholesteryl ester transfer in diabetes

Robin P. F. Dullaart; Rindert de Vries; Arjan J. Kwakernaak; Frank Perton; Geesje M. Dallinga-Thie

doi:10.1111/eci.12377

Increased large VLDL particles confer elevated cholesteryl ester transfer in diabetes

Robin P. F. Dullaart^*, Rindert de Vries, Arjan J. Kwakernaak, Frank Perton, Geesje M. Dallinga-Thie

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

BackgroundPlasma cholesteryl ester transfer (CET), reflecting transfer of cholesteryl esters from high density lipoproteins (HDL) towards apolipoprotein B-containing lipoproteins, may promote atherosclerosis development, and is elevated in Type 2 diabetes mellitus (T2DM). We determined the extent to which the relationship of plasma CET with very low density lipoprotein (VLDL) and low density lipoprotein (LDL) subfractions is modified in T2DM.

Materials and methodsPlasma CET, cholesteryl ester transfer protein (CETP) mass, as well as VLDL and LDL subfractions (nuclear magnetic resonance spectroscopy) were determined in 62 patients with T2DM and 53 nondiabetic subjects.

ResultsPlasma CET and CETP mass were increased in T2DM, coinciding higher triglycerides and large VLDL particles (all P015).

ConclusionAbnormalities in the concentration and composition of large VLDL particles are likely to contribute to elevated plasma CET in T2DM.

Original language	English
Pages (from-to)	36-44
Number of pages	9
Journal	European Journal of Clinical Investigation
Volume	45
Issue number	1
DOIs	https://doi.org/10.1111/eci.12377
Publication status	Published - Jan-2015

Keywords

Cholesteryl ester transfer
lipoprotein subfractions
low density lipoproteins
nuclear magnetic resonance spectroscopy
Type 2 diabetes mellitus
very low density lipoproteins
NUCLEAR-MAGNETIC-RESONANCE
PHOSPHOLIPID TRANSFER PROTEIN
HIGH-DENSITY-LIPOPROTEINS
LIPID TRANSFER PROTEINS
INSULIN-RESISTANCE
TRANSFER RATES
RISK
MELLITUS
DISEASE
SIZE

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Increased large VLDL particles confer elevated cholesteryl ester transfer in diabetes
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@article{8a8cc12455e8486e871603c424e2e4cd,

title = "Increased large VLDL particles confer elevated cholesteryl ester transfer in diabetes",

abstract = "BackgroundPlasma cholesteryl ester transfer (CET), reflecting transfer of cholesteryl esters from high density lipoproteins (HDL) towards apolipoprotein B-containing lipoproteins, may promote atherosclerosis development, and is elevated in Type 2 diabetes mellitus (T2DM). We determined the extent to which the relationship of plasma CET with very low density lipoprotein (VLDL) and low density lipoprotein (LDL) subfractions is modified in T2DM.Materials and methodsPlasma CET, cholesteryl ester transfer protein (CETP) mass, as well as VLDL and LDL subfractions (nuclear magnetic resonance spectroscopy) were determined in 62 patients with T2DM and 53 nondiabetic subjects.ResultsPlasma CET and CETP mass were increased in T2DM, coinciding higher triglycerides and large VLDL particles (all P015).ConclusionAbnormalities in the concentration and composition of large VLDL particles are likely to contribute to elevated plasma CET in T2DM.",

keywords = "Cholesteryl ester transfer, lipoprotein subfractions, low density lipoproteins, nuclear magnetic resonance spectroscopy, Type 2 diabetes mellitus, very low density lipoproteins, NUCLEAR-MAGNETIC-RESONANCE, PHOSPHOLIPID TRANSFER PROTEIN, HIGH-DENSITY-LIPOPROTEINS, LIPID TRANSFER PROTEINS, INSULIN-RESISTANCE, TRANSFER RATES, RISK, MELLITUS, DISEASE, SIZE",

author = "Dullaart, {Robin P. F.} and {de Vries}, Rindert and Kwakernaak, {Arjan J.} and Frank Perton and Dallinga-Thie, {Geesje M.}",

year = "2015",

month = jan,

doi = "10.1111/eci.12377",

language = "English",

volume = "45",

pages = "36--44",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - Increased large VLDL particles confer elevated cholesteryl ester transfer in diabetes

AU - Dullaart, Robin P. F.

AU - de Vries, Rindert

AU - Kwakernaak, Arjan J.

AU - Perton, Frank

AU - Dallinga-Thie, Geesje M.

PY - 2015/1

Y1 - 2015/1

N2 - BackgroundPlasma cholesteryl ester transfer (CET), reflecting transfer of cholesteryl esters from high density lipoproteins (HDL) towards apolipoprotein B-containing lipoproteins, may promote atherosclerosis development, and is elevated in Type 2 diabetes mellitus (T2DM). We determined the extent to which the relationship of plasma CET with very low density lipoprotein (VLDL) and low density lipoprotein (LDL) subfractions is modified in T2DM.Materials and methodsPlasma CET, cholesteryl ester transfer protein (CETP) mass, as well as VLDL and LDL subfractions (nuclear magnetic resonance spectroscopy) were determined in 62 patients with T2DM and 53 nondiabetic subjects.ResultsPlasma CET and CETP mass were increased in T2DM, coinciding higher triglycerides and large VLDL particles (all P015).ConclusionAbnormalities in the concentration and composition of large VLDL particles are likely to contribute to elevated plasma CET in T2DM.

AB - BackgroundPlasma cholesteryl ester transfer (CET), reflecting transfer of cholesteryl esters from high density lipoproteins (HDL) towards apolipoprotein B-containing lipoproteins, may promote atherosclerosis development, and is elevated in Type 2 diabetes mellitus (T2DM). We determined the extent to which the relationship of plasma CET with very low density lipoprotein (VLDL) and low density lipoprotein (LDL) subfractions is modified in T2DM.Materials and methodsPlasma CET, cholesteryl ester transfer protein (CETP) mass, as well as VLDL and LDL subfractions (nuclear magnetic resonance spectroscopy) were determined in 62 patients with T2DM and 53 nondiabetic subjects.ResultsPlasma CET and CETP mass were increased in T2DM, coinciding higher triglycerides and large VLDL particles (all P015).ConclusionAbnormalities in the concentration and composition of large VLDL particles are likely to contribute to elevated plasma CET in T2DM.

KW - Cholesteryl ester transfer

KW - lipoprotein subfractions

KW - low density lipoproteins

KW - nuclear magnetic resonance spectroscopy

KW - Type 2 diabetes mellitus

KW - very low density lipoproteins

KW - NUCLEAR-MAGNETIC-RESONANCE

KW - PHOSPHOLIPID TRANSFER PROTEIN

KW - HIGH-DENSITY-LIPOPROTEINS

KW - LIPID TRANSFER PROTEINS

KW - INSULIN-RESISTANCE

KW - TRANSFER RATES

KW - RISK

KW - MELLITUS

KW - DISEASE

KW - SIZE

U2 - 10.1111/eci.12377

DO - 10.1111/eci.12377

M3 - Article

SN - 0014-2972

VL - 45

SP - 36

EP - 44

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 1

ER -

Increased large VLDL particles confer elevated cholesteryl ester transfer in diabetes

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