Independent regulation of M-CSF and G-CSF gene expression in human monocytes

E. Vellenga, A. Rambaldi, T. J. Ernst, D. Ostapovicz, J. D. Griffin

Research output: Contribution to journalArticleAcademicpeer-review

179 Citations (Scopus)

Abstract

The macrophage and granulocyte colony-stimulating factors, M-CSF and G-CSF, act in vitro to induce proliferation and differentiation of monocyte and granulocyte progenitor cells, respectively. We show here that both of these CSFs can be produced by stimulated human blood monocytes, but the M-CSF and G-CSF genes are independently regulated. Recombinant human interleukin-3 (IL-3) and GM-CSF primarily induce expressiopn of the M-CSF gene and secretion of M-CSF, whereas bacterial lipopolysaccharide primarily induces expression of the G-CSF gene and secretion of G-CSF. These results suggest that under different conditions of in vitro stimulation the monocyte secretes factors that could lead selectively to either granulocyte or monocyte production.

Original languageEnglish
Pages (from-to)1529-1532
Number of pages4
JournalBlood
Volume71
Issue number6
DOIs
Publication statusPublished - 1988
Externally publishedYes

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