Indicators of long chain polyunsaturated fatty acid status of exclusively breastfed infants at delivery and after 20–22 days

C.M. van Beusekom*, H.J. Nijeboer, C.N. van der Veere, A.J. Luteyn, P.J. Offringa, F.A.J. Muskiet, E.R. Boersma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Abstract

The fatty acid composition of plasma cholesterol esters (CE), erythrocytes (RBC) and mature milk from seven lactating /women and their exclusively breastfed newborns, living on Dominica, were studied. Blood samples were taken from umbilical cord and mother at birth. A sample of breastmilk was collected on day 20-22 postpartum, together with a blood sample from the baby. At birth, cord blood plasma CE and RBC total long chain polyunsaturated fatty acid (LC-PUFA) contents were higher, and linoleic (18:2c,omega6) and alpha-linolenic (18:3c,omega3) acid contents lower, than in corresponding maternal compartments. Cord blood RBC LC-PUFA omega3 content was lower and LC-PUFA omega6 content higher than in maternal RBC. After birth, feeding with human milk led to a drop in LC-PUFA content in the plasma CE fraction, whereas RBC LC-PUFA content remained virtually constant. Current understanding of the origin and relative affinity of fatty acids incorporated in plasma CE and RBC suggests that RBC LC-PUFA content is a more reliable parameter for LC-PUFA status than plasma CE LC-PUFA content. The RBC LC-PUFA data suggest therefore that at birth the newborn has a lower LC-PUFA omega3 status than the mother, and that this does not change during three weeks of exclusive breastfeeding.

Original languageEnglish
Pages (from-to)207-218
Number of pages12
JournalEarly Human Development
Volume32
Issue number2-3
DOIs
Publication statusPublished - Mar-1993

Keywords

  • NEWBORN
  • LONG CHAIN POLYUNSATURATED FATTY ACIDS
  • PLASMA CHOLESTEROL ESTERS
  • ERYTHROCYTES
  • HUMAN MILK
  • CAPILLARY GAS-CHROMATOGRAPHY
  • ALPHA-FETOPROTEIN
  • LIPID-COMPOSITION
  • SPLIT INJECTION
  • METHYL-ESTERS
  • MEMBRANE
  • PLASMA
  • PHOSPHATIDYLCHOLINE
  • CHOLESTEROL

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