Individual differences in the encoding of contextual details following acute stress: An explorative study

Milou S. C. Sep*, Marian Joels, Elbert Geuze

*Corresponding author for this work

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    Abstract

    Information processing under stressful circumstances depends on many experimental conditions, like the information valence or the point in time at which brain function is probed. This also holds true for memorizing contextual details (or 'memory contextualization'). Moreover, large interindividual differences appear to exist in (context-dependent) memory formation after stress, but it is mostly unknown which individual characteristics are essential. Various characteristics were explored from a theory-driven and data-driven perspective, in 120 healthy men. In the theory-driven model, we postulated that life adversity and trait anxiety shape the stress response, which impacts memory contextualization following acute stress. This was indeed largely supported by linear regression analyses, showing significant interactions depending on valence and time point after stress. Thus, during the acute phase of the stress response, reduced neutral memory contextualization was related to salivary cortisol level; moreover, certain individual characteristics correlated with memory contextualization of negatively valenced material: (a) life adversity, (b) alpha-amylase reactivity in those with low life adversity and (c) cortisol reactivity in those with low trait anxiety. Better neutral memory contextualization during the recovery phase of the stress response was associated with (a) cortisol in individuals with low life adversity and (b) alpha-amylase in individuals with high life adversity. The data-driven Random Forest-based variable selection also pointed to (early) life adversity-during the acute phase-and (moderate) alpha-amylase reactivity-during the recovery phase-as individual characteristics related to better memory contextualization. Newly identified characteristics sparked novel hypotheses about non-anxious personality traits, age, mood and states during retrieval of context-related information.

    Original languageEnglish
    Pages (from-to)1-25
    Number of pages25
    JournalEuropean Journal of Neuroscience
    DOIs
    Publication statusPublished - 15-Dec-2020

    Keywords

    • life adversity
    • linear regression analysis
    • random forest analysis
    • SAM&#8208
    • axis
    • HPA&#8208
    • EMOTIONAL MEMORY
    • DEPRESSION RISK
    • ANXIETY TRAIT
    • RESPONSES
    • CORTISOL
    • FEAR
    • HORMONE
    • GLUCOCORTICOIDS
    • PERSONALITY
    • EXTINCTION

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