Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity

S. Sleijfer; Z. Vujaskovic; PC Limburg; NH Mulder; H. Schraffordt Koops

doi:10.1002/(SICI)1097-0142(19980301)82:5<970::AID-CNCR24>3.0.CO;2-X

Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity

S. Sleijfer, Z. Vujaskovic, PC Limburg, NH Mulder^*, H. Schraffordt Koops

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

Abstract

BACKGROUND, The application of bleomycin is characterized by acute side effects, such as fever, chills, and sometimes hypotension and tachypnea. Furthermore, bleomycin is known to induce pneumonitis. There are several indications that the induction of cytokines by bleomycin is involved in the development of these side effects.

METHODS, In this study, the authors determined the plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and transforming growth factor-beta (TGF-beta) before and after bleomycin infusion in 14 patients treated for disseminated nonseminomatous germ cell tumor.

RESULTS, Compared with the pretreatment value, TNF-alpha was significantly increased 3, 4.5, and 24 hours after bleomycin infusion. For IL-1 beta and TGF-beta, no significant alterations were observed within 24 hours after administration of bleomycin.

CONCLUSIONS. The increase in TNF-alpha after administration of bleomycin suggests a role for this cytokine in the development of the acute side effects and probably also in the occurrence of bleomycin-induced pulmonary toxicity. The involvement of IL-1 beta and TGF-beta deserve further study. (C) 1998 American Cancer Society.

Original language	English
Pages (from-to)	970-974
Number of pages	5
Journal	Cancer
Volume	82
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1097-0142(19980301)82:5<970::AID-CNCR24>3.0.CO;2-X
Publication status	Published - 1-Mar-1998

Keywords

bleomycin
toxicity
germ cell tumor
tumor necrosis factor-alpha
interleukin-1 beta
transforming growth factor-beta
GROWTH-FACTOR-BETA
INDUCED PULMONARY FIBROSIS
RECOMBINANT INTERLEUKIN-1-BETA
COMBINATION CHEMOTHERAPY
CELL-PROLIFERATION
INTERFERON-GAMMA
FACTOR CACHECTIN
PHASE-I
EXPRESSION
MICE

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title = "Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity",

abstract = "BACKGROUND, The application of bleomycin is characterized by acute side effects, such as fever, chills, and sometimes hypotension and tachypnea. Furthermore, bleomycin is known to induce pneumonitis. There are several indications that the induction of cytokines by bleomycin is involved in the development of these side effects.METHODS, In this study, the authors determined the plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and transforming growth factor-beta (TGF-beta) before and after bleomycin infusion in 14 patients treated for disseminated nonseminomatous germ cell tumor.RESULTS, Compared with the pretreatment value, TNF-alpha was significantly increased 3, 4.5, and 24 hours after bleomycin infusion. For IL-1 beta and TGF-beta, no significant alterations were observed within 24 hours after administration of bleomycin.CONCLUSIONS. The increase in TNF-alpha after administration of bleomycin suggests a role for this cytokine in the development of the acute side effects and probably also in the occurrence of bleomycin-induced pulmonary toxicity. The involvement of IL-1 beta and TGF-beta deserve further study. (C) 1998 American Cancer Society.",

keywords = "bleomycin, toxicity, germ cell tumor, tumor necrosis factor-alpha, interleukin-1 beta, transforming growth factor-beta, GROWTH-FACTOR-BETA, INDUCED PULMONARY FIBROSIS, RECOMBINANT INTERLEUKIN-1-BETA, COMBINATION CHEMOTHERAPY, CELL-PROLIFERATION, INTERFERON-GAMMA, FACTOR CACHECTIN, PHASE-I, EXPRESSION, MICE",

author = "S. Sleijfer and Z. Vujaskovic and PC Limburg and NH Mulder and {Schraffordt Koops}, H.",

year = "1998",

month = mar,

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doi = "10.1002/(SICI)1097-0142(19980301)82:5<970::AID-CNCR24>3.0.CO;2-X",

language = "English",

volume = "82",

pages = "970--974",

journal = "Cancer",

issn = "0008-543X",

publisher = "Wiley",

number = "5",

}

TY - JOUR

T1 - Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity

AU - Sleijfer, S.

AU - Vujaskovic, Z.

AU - Limburg, PC

AU - Mulder, NH

AU - Schraffordt Koops, H.

PY - 1998/3/1

Y1 - 1998/3/1

N2 - BACKGROUND, The application of bleomycin is characterized by acute side effects, such as fever, chills, and sometimes hypotension and tachypnea. Furthermore, bleomycin is known to induce pneumonitis. There are several indications that the induction of cytokines by bleomycin is involved in the development of these side effects.METHODS, In this study, the authors determined the plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and transforming growth factor-beta (TGF-beta) before and after bleomycin infusion in 14 patients treated for disseminated nonseminomatous germ cell tumor.RESULTS, Compared with the pretreatment value, TNF-alpha was significantly increased 3, 4.5, and 24 hours after bleomycin infusion. For IL-1 beta and TGF-beta, no significant alterations were observed within 24 hours after administration of bleomycin.CONCLUSIONS. The increase in TNF-alpha after administration of bleomycin suggests a role for this cytokine in the development of the acute side effects and probably also in the occurrence of bleomycin-induced pulmonary toxicity. The involvement of IL-1 beta and TGF-beta deserve further study. (C) 1998 American Cancer Society.

AB - BACKGROUND, The application of bleomycin is characterized by acute side effects, such as fever, chills, and sometimes hypotension and tachypnea. Furthermore, bleomycin is known to induce pneumonitis. There are several indications that the induction of cytokines by bleomycin is involved in the development of these side effects.METHODS, In this study, the authors determined the plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and transforming growth factor-beta (TGF-beta) before and after bleomycin infusion in 14 patients treated for disseminated nonseminomatous germ cell tumor.RESULTS, Compared with the pretreatment value, TNF-alpha was significantly increased 3, 4.5, and 24 hours after bleomycin infusion. For IL-1 beta and TGF-beta, no significant alterations were observed within 24 hours after administration of bleomycin.CONCLUSIONS. The increase in TNF-alpha after administration of bleomycin suggests a role for this cytokine in the development of the acute side effects and probably also in the occurrence of bleomycin-induced pulmonary toxicity. The involvement of IL-1 beta and TGF-beta deserve further study. (C) 1998 American Cancer Society.

KW - bleomycin

KW - toxicity

KW - germ cell tumor

KW - tumor necrosis factor-alpha

KW - interleukin-1 beta

KW - transforming growth factor-beta

KW - GROWTH-FACTOR-BETA

KW - INDUCED PULMONARY FIBROSIS

KW - RECOMBINANT INTERLEUKIN-1-BETA

KW - COMBINATION CHEMOTHERAPY

KW - CELL-PROLIFERATION

KW - INTERFERON-GAMMA

KW - FACTOR CACHECTIN

KW - PHASE-I

KW - EXPRESSION

KW - MICE

U2 - 10.1002/(SICI)1097-0142(19980301)82:5<970::AID-CNCR24>3.0.CO;2-X

DO - 10.1002/(SICI)1097-0142(19980301)82:5<970::AID-CNCR24>3.0.CO;2-X

M3 - Article

SN - 0008-543X

VL - 82

SP - 970

EP - 974

JO - Cancer

JF - Cancer

IS - 5

ER -

Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity

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