Infection prevention in a connected world: The case for a regional approach

Mariano Ciccolini, Tjibbe Donker, Robin Köck, Martin Mielke, Ron Hendrix, Annette Jurke, Janette Rahamat-Langendoen, Karsten Becker, Hubert G M Niesters, Hajo Grundmann, Alexander W Friedrich

Research output: Contribution to journalReview articleAcademicpeer-review

43 Citations (Scopus)

Abstract

Results from microbiological and epidemiological investigations, as well as mathematical modelling, show that the transmission dynamics of nosocomial pathogens, especially of multiple antibiotic-resistant bacteria, is not exclusively amenable to single-hospital infection prevention measures. Crucially, their extent of spread depends on the structure of an underlying "healthcare network", as determined by inter-institutional referrals of patients. The current trend towards centralized healthcare systems favours the spread of hospital-associated pathogens, and must be addressed by coordinated regional or national approaches to infection prevention in order to maintain patient safety. Here we review recent advances that support this hypothesis, and propose a "next-generation" network-approach to hospital infection prevention and control.

Original languageEnglish
Pages (from-to)380-387
Number of pages8
JournalInternational journal of medical microbiology
Volume303
Issue number6-7
DOIs
Publication statusPublished - Aug-2013

Keywords

  • Healthcare networks
  • Network analysis
  • Regional networks
  • Infection prevention and control
  • RESISTANT STAPHYLOCOCCUS-AUREUS
  • HEALTH-CARE FACILITIES
  • ANTIBIOTIC-RESISTANCE
  • ORANGE-COUNTY
  • SPREAD
  • MRSA
  • HOSPITALS
  • TRANSMISSION
  • ENTEROCOCCUS
  • SIMULATION

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