Infection resistance of degradable versus non-degradable biomaterials: An assessment of the potential mechanisms

Seyedmojtaba Daghighi, Jelmer Sjollema*, Henny C. van der Mei, Henk J. Busscher, Edward T. J. Rochford

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

79 Citations (Scopus)

Abstract

Extended life expectancy and medical development has led to an increased reliance on biomaterial implants and devices to support or restore human anatomy and function. However, the presence of an implanted biomaterial results in an increased susceptibility to infection. Due to the severity of the potential outcomes of biomaterial-associated infection, different strategies have been employed to reduce the infection risk. Interestingly, degradable biological materials demonstrate increased resistance to bacterial infection compared to non-degradable synthetic biomaterials. Current knowledge about the specific mechanisms of how degradable biological materials are afforded increased resistance to infection is limited. Therefore, in this paper a number of hypotheses to explain the decreased infection risk associated with the use of degradable versus non-degradable biomaterials are evaluated and discussed with reference to the present state of knowledge. (c) 2013 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)8013-8017
Number of pages5
JournalBiomaterials
Volume34
Issue number33
DOIs
Publication statusPublished - Nov-2013

Keywords

  • Degradation
  • Foreign body response
  • Immune response
  • Infection
  • PROTECTS STAPHYLOCOCCUS-EPIDERMIDIS
  • VASCULAR CATHETER MATERIAL
  • ABDOMINAL-WALL DEFECTS
  • HERNIA REPAIR
  • IN-VITRO
  • INTESTINAL SUBMUCOSA
  • EXTRACELLULAR-MATRIX
  • BACTERIAL BIOFILMS
  • CLINICAL-EVIDENCE
  • DERMAL COLLAGEN

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