Infiltrating CTLs are bothered by HLA-E on tumors

Marloes J. M. Gooden, Thorbald van Hall*

*Corresponding author for this work

    Research output: Contribution to journalEditorialAcademicpeer-review

    10 Citations (Scopus)

    Abstract

    We recently described the upregulation of HLA-E in ovarian and cervical cancers. Instead of interacting with natural killer cells, HLA-E appeared to inhibit intratumoral cytotoxic T lymphocytes (CTL) via the receptor CD94/NKG2A. Strikingly, the survival benefit of intraepithelial infiltrating CTL was lost in those cancers with high HLA-E expression.

    Original languageEnglish
    Pages (from-to)92-93
    Number of pages2
    JournalOncoImmunology
    Volume1
    Issue number1
    DOIs
    Publication statusPublished - 2012

    Keywords

    • CD8(+) T-LYMPHOCYTES
    • CANCER
    • EXPRESSION
    • CARCINOMA

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