Abstract
Aims Anaemia in heart failure (HF) is associated with a poor prognosis. Although inflammation is assumed to be an important cause of anaemia, the association between anaemia and inflammatory markers in patients with HF has not been well established.
Methods Data from a multicentre randomised clinical trial, in which patients were eligible if they were >18 years of age and admitted for HF (New York Heart Association II-IV), were used. In a subset of 326 patients, haemoglobin (Hb), haematocrit, high sensitivity C-reactive protein (hsCRP), interleukin-(IL) 6, soluble tumour necrosis factor receptor (sTNFR)-1 and erythropoietin (Epo) were measured at discharge and the primary endpoint was all-cause mortality. Follow-up was 18 months.
Results Anaemia (Hb
Conclusion Anaemia is present in 40% of patients hospitalised for HF and is independently associated with inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 1237-1241 |
| Number of pages | 5 |
| Journal | Heart |
| Volume | 98 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Aug-2012 |
Keywords
- TUMOR-NECROSIS-FACTOR
- BLUNTED ERYTHROPOIETIN PRODUCTION
- RENAL-FUNCTION
- ENDOGENOUS ERYTHROPOIETIN
- PROGNOSTIC VALUE
- IRON-DEFICIENCY
- CHRONIC DISEASE
- FACTOR-ALPHA
- BONE-MARROW
- MORTALITY