Inflammation-induced changes in expression and glycosylation of genetic variants of α1-acid glycoprotein: Studies with human sera, primary cultures of human hepatocytes and transgenic mice

W. Van Dijk; O. Pos; M. E. Van der Stelt; H. J. Moshage; S. H. Yap; L. Dente; P. Baumann; C. B. Eap

doi:10.1042/bj2760343

Inflammation-induced changes in expression and glycosylation of genetic variants of α₁-acid glycoprotein: Studies with human sera, primary cultures of human hepatocytes and transgenic mice

W. Van Dijk^*
, O. Pos
, M. E. Van der Stelt
, H. J. Moshage
, S. H. Yap
, L. Dente
, P. Baumann
, C. B. Eap

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

54 Citations (Scopus)

Abstract

The relative occurrence of genetic variants of human α₁-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.

Original language	English
Pages (from-to)	343-347
Number of pages	5
Journal	Biochemical Journal
Volume	276
Issue number	2
DOIs	https://doi.org/10.1042/bj2760343
Publication status	Published - 1991
Externally published	Yes

Access to Document

10.1042/bj2760343

Handle.net

Persistent link

Cite this

Van Dijk, W., Pos, O., Van der Stelt, M. E., Moshage, H. J., Yap, S. H., Dente, L., Baumann, P., & Eap, C. B. (1991). Inflammation-induced changes in expression and glycosylation of genetic variants of α₁-acid glycoprotein: Studies with human sera, primary cultures of human hepatocytes and transgenic mice. Biochemical Journal, 276(2), 343-347. https://doi.org/10.1042/bj2760343

@article{9615d94614144ce0ad8363cce23e9503,

title = "Inflammation-induced changes in expression and glycosylation of genetic variants of α1-acid glycoprotein: Studies with human sera, primary cultures of human hepatocytes and transgenic mice",

abstract = "The relative occurrence of genetic variants of human α1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.",

author = "\{Van Dijk\}, W. and O. Pos and \{Van der Stelt\}, \{M. E.\} and Moshage, \{H. J.\} and Yap, \{S. H.\} and L. Dente and P. Baumann and Eap, \{C. B.\}",

year = "1991",

doi = "10.1042/bj2760343",

language = "English",

volume = "276",

pages = "343--347",

journal = "Biochemical Journal",

issn = "0264-6021",

publisher = "PORTLAND PRESS LTD",

number = "2",

}

Van Dijk, W, Pos, O, Van der Stelt, ME, Moshage, HJ, Yap, SH, Dente, L, Baumann, P & Eap, CB 1991, 'Inflammation-induced changes in expression and glycosylation of genetic variants of α₁-acid glycoprotein: Studies with human sera, primary cultures of human hepatocytes and transgenic mice', Biochemical Journal, vol. 276, no. 2, pp. 343-347. https://doi.org/10.1042/bj2760343

Inflammation-induced changes in expression and glycosylation of genetic variants of α₁-acid glycoprotein: Studies with human sera, primary cultures of human hepatocytes and transgenic mice. / Van Dijk, W.; Pos, O.; Van der Stelt, M. E. et al.
In: Biochemical Journal, Vol. 276, No. 2, 1991, p. 343-347.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Inflammation-induced changes in expression and glycosylation of genetic variants of α1-acid glycoprotein

T2 - Studies with human sera, primary cultures of human hepatocytes and transgenic mice

AU - Van Dijk, W.

AU - Pos, O.

AU - Van der Stelt, M. E.

AU - Moshage, H. J.

AU - Yap, S. H.

AU - Dente, L.

AU - Baumann, P.

AU - Eap, C. B.

PY - 1991

Y1 - 1991

N2 - The relative occurrence of genetic variants of human α1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.

AB - The relative occurrence of genetic variants of human α1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.

U2 - 10.1042/bj2760343

DO - 10.1042/bj2760343

M3 - Article

C2 - 1646598

AN - SCOPUS:0025856579

SN - 0264-6021

VL - 276

SP - 343

EP - 347

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2