TY - JOUR
T1 - Inflammatory marker trajectories associated with frailty and ageing in a 20-year longitudinal study
AU - Samson, Leonard Daniël
AU - Buisman, Anne Marie
AU - Ferreira, José A.
AU - Picavet, H. Susan J.
AU - Verschuren, W. M.Monique
AU - Boots, Annemieke M.H.
AU - Engelfriet, Peter
N1 - Funding Information:
We thank the DCS respondents for their participation in the study and the epidemiologists and fieldworkers of the Municipal Health Service in Doetinchem for their contribution to the data collection. In addition, we thank Petra Vissink for her help with the blood sample collection. Figure 1, Figure 7a and the graphical abstract in the online version were created using BioRender.com.
Publisher Copyright:
© 2022 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
PY - 2022
Y1 - 2022
N2 - Objective: The aim of this exploratory study was to investigate the development of low-grade inflammation during ageing and its relationship with frailty.Methods: The trajectories of 18 inflammatory markers measured in blood samples, collected at 5-year intervals over a period of 20 years from 144 individuals aged 65–75 years at the study endpoint, were related to the degree of frailty later in life.Results: IFN-γ-related markers and platelet activation markers were found to change in synchrony. Chronically elevated levels of IL-6 pathway markers, such as CRP and sIL-6R, were associated with more frailty, poorer lung function and reduced physical strength. Being overweight was a possible driver of these associations. More and stronger associations were detected in women, such as a relation between increasing sCD14 levels and frailty, indicating a possible role for monocyte overactivation. Multivariate prediction of frailty confirmed the main results, but predictive accuracy was low.Conclusion: In summary, we documented temporal changes in and between inflammatory markers in an ageing population over a period of 20 years, and related these to clinically relevant health outcomes.
AB - Objective: The aim of this exploratory study was to investigate the development of low-grade inflammation during ageing and its relationship with frailty.Methods: The trajectories of 18 inflammatory markers measured in blood samples, collected at 5-year intervals over a period of 20 years from 144 individuals aged 65–75 years at the study endpoint, were related to the degree of frailty later in life.Results: IFN-γ-related markers and platelet activation markers were found to change in synchrony. Chronically elevated levels of IL-6 pathway markers, such as CRP and sIL-6R, were associated with more frailty, poorer lung function and reduced physical strength. Being overweight was a possible driver of these associations. More and stronger associations were detected in women, such as a relation between increasing sCD14 levels and frailty, indicating a possible role for monocyte overactivation. Multivariate prediction of frailty confirmed the main results, but predictive accuracy was low.Conclusion: In summary, we documented temporal changes in and between inflammatory markers in an ageing population over a period of 20 years, and related these to clinically relevant health outcomes.
KW - chemokines
KW - chronic low-grade inflammation
KW - cytokines
KW - frailty
KW - healthy ageing
KW - longitudinal study
U2 - 10.1002/cti2.1374
DO - 10.1002/cti2.1374
M3 - Article
AN - SCOPUS:85125133269
SN - 2050-0068
VL - 11
JO - Clinical and Translational Immunology
JF - Clinical and Translational Immunology
IS - 2
M1 - e1374
ER -