Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Kunliang Qiu, Geng Wang, Riping Zhang, Xuehui Lu, Mingzhi Zhang*, Nomdo M. Jansonius

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
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Abstract

Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and ss-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24-25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from -0.27 to -0.47), except for the temporal outer (r = -0.15, P = 0.089) and inferior outer (r = -0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P <0.001), independent of ocular magnification and other covariates. Our findings indicate that eyes with a greater DFD have a lower macular thickness.

Original languageEnglish
Article number5233
Number of pages8
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 27-Mar-2018

Keywords

  • FIBER LAYER THICKNESS
  • COHERENCE TOMOGRAPHY
  • PATHOLOGICAL MYOPIA
  • 3-DIMENSIONAL PROFILE
  • RETINAL THICKNESS
  • AXIAL LENGTH
  • RISK-FACTORS
  • NERVE
  • GLAUCOMA
  • AGE

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