Abstract
Background and objectives In the albumin-to-creatinine ratio (spot-ACR), urine creatinine corrects for tonicity but also reflects muscle mass. Low muscle mass is associated with cardiovascular disease (CVD). We hypothesized that the spot-ACR would be higher in women, lower-weight persons, and older individuals, independent of timed urine albumin excretion (24hr-UAE), and accordingly, that spot-ACR would be more strongly associated with CVD events than 24hr-UAE in these subgroups.
Design, setting, participants, & methods 2627 PREVEND (Prevention of Renal and Vascular End-stage Disease) participants with 24hr-UAE
Results Female sex (26%), lower weight (2% per 5 kg), and older age (4% per 5 years) were associated with higher spot-ACR independent of 24hr-UAE (P= 10 mg/g versus less (FIR, 2.33) and 24hr-UAE >= 10 mg/d versus less (HR, 2.09) with CVD events were similar, and there were no significant differences across subgroups (P for interactions >0.06).
Conclusions In community-living individuals with 24hr-UAE
| Original language | English |
|---|---|
| Pages (from-to) | 595-603 |
| Number of pages | 9 |
| Journal | Clinical Journal of the American Society of Nephrology |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr-2012 |
Keywords
- GLOMERULAR-FILTRATION-RATE
- ABNORMAL DIURNAL RHYTHM
- MUSCLE MASS
- BLOOD-PRESSURE
- ALBUMIN/CREATININE RATIO
- NONDIABETIC INDIVIDUALS
- EXCRETION
- RISK
- MICROALBUMINURIA
- DISEASE
Fingerprint
Dive into the research topics of 'Influence of Urine Creatinine on the Relationship between the Albumin-to-Creatinine Ratio and Cardiovascular Events'. Together they form a unique fingerprint.Datasets
-
Prevention of Renal and Vascular End-stage Disease (PREVEND)
Gansevoort, R. T. (Creator), University of Groningen, 2017
Dataset