TY - JOUR
T1 - Initial Characterization of the SAFIR Prototype PET-MR Scanner
AU - Ritzer, Christian
AU - Becker, Robert
AU - Buck, Alfred
AU - Commichau, Volker
AU - Debus, Jan
AU - Djambazov, Lubomir
AU - Eleftheriou, Afroditi
AU - Fischer, Jannis
AU - Fischer, Peter
AU - Ito, Mikiko
AU - Khateri, Parisa
AU - Lustermann, Werner
AU - Ritzert, Michael
AU - Roser, Ulf
AU - Rudin, Markus
AU - Sacco, Ilaria
AU - Tsoumpas, Charalampos
AU - Warnock, Geoffrey
AU - Wyss, Matthias
AU - Zagozdzinska-Bochenek, Agnieszka
AU - Weber, Bruno
AU - Dissertori, Gunther
PY - 2020/9
Y1 - 2020/9
N2 - The SAFIR collaboration is currently developing a high-rate positron emission tomography (PET) insert to study fast kinetic processes in small animals. Our insert is designed for simultaneous image acquisition with a preclinical 7 T magnetic resonance (MR) imaging device. In contrast to existing preclinical PET scanners and inserts, our hardware is optimized for high-rate measurements with source activities up to 500 MBq. As a first step, the SAFIR Prototype insert was constructed. This already incorporates the final components, but has a reduced axial field-of-view (35.6 mm). We use lutetiumyttrium oxyorthosilicate crystals (2.12 mm x 2.12 mm x 13 mm) one-to-one coupled to silicon photomultipliers. All analog signals are digitized within the insert. We use 49 MR-compatible dcdc converters in the insert to provide the power to all readout electronics. After shimming, no degradation of the homogeneity of the static B-0 field in the MR scanner was observed. During full operation, we saw a minor reduction in the signal-to-noise ratio of the MR data of 4.9%. With a low activity point source (22Na 0.65 MBq) we obtained a coincidence energy resolution of 13.8% full width at half maximum (FWHM) and a coincidence timing resolution of 194 ps (FWHM). First PET/MR rat brain and high-rate mouse cardiac images (84.9 MBq) are shown in this article.
AB - The SAFIR collaboration is currently developing a high-rate positron emission tomography (PET) insert to study fast kinetic processes in small animals. Our insert is designed for simultaneous image acquisition with a preclinical 7 T magnetic resonance (MR) imaging device. In contrast to existing preclinical PET scanners and inserts, our hardware is optimized for high-rate measurements with source activities up to 500 MBq. As a first step, the SAFIR Prototype insert was constructed. This already incorporates the final components, but has a reduced axial field-of-view (35.6 mm). We use lutetiumyttrium oxyorthosilicate crystals (2.12 mm x 2.12 mm x 13 mm) one-to-one coupled to silicon photomultipliers. All analog signals are digitized within the insert. We use 49 MR-compatible dcdc converters in the insert to provide the power to all readout electronics. After shimming, no degradation of the homogeneity of the static B-0 field in the MR scanner was observed. During full operation, we saw a minor reduction in the signal-to-noise ratio of the MR data of 4.9%. With a low activity point source (22Na 0.65 MBq) we obtained a coincidence energy resolution of 13.8% full width at half maximum (FWHM) and a coincidence timing resolution of 194 ps (FWHM). First PET/MR rat brain and high-rate mouse cardiac images (84.9 MBq) are shown in this article.
KW - High rate PET
KW - instrumentation
KW - molecular imaging
KW - multimodality imaging
KW - positron emission tomography (PET)/magnetic resonance (MR)
KW - preclinical PET insert
KW - SAFIR
KW - TOF-PET
KW - INTER-CRYSTAL SCATTER
KW - PERFORMANCE EVALUATION
KW - INSERT
KW - PET/MRI
U2 - 10.1109/TRPMS.2020.2980072
DO - 10.1109/TRPMS.2020.2980072
M3 - Article
SN - 2469-7311
VL - 4
SP - 613
EP - 621
JO - IEEE Transactions on Radiation and Plasma Medical Sciences
JF - IEEE Transactions on Radiation and Plasma Medical Sciences
IS - 5
ER -