Innovative and rapid antimicrobial susceptibility testing systems

Alex van Belkum*, Carey-Ann D. Burnham, John W. A. Rossen, Frederic Mallard, Olivier Rochas, William Michael Dunne

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

47 Citations (Scopus)

Abstract

Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid detection and quantification of resistance, combined with antimicrobial stewardship, are key interventions to combat the spread and emergence of AMR. Antimicrobial susceptibility testing (AST) systems are the collective set of diagnostic processes that facilitate the phenotypic and genotypic assessment of AMR and antibiotic susceptibility. Over the past 30 years, only a few high-throughput AST methods have been developed and widely implemented. By contrast, several studies have established proof of principle for various innovative AST methods, including both molecular-based and genome-based methods, which await clinical trials and regulatory review. In this Review, we discuss the current state of AST systems in the broadest technical, translational and implementation-related scope.

Original languageEnglish
Pages (from-to)299-311
Number of pages13
JournalNature Reviews Microbiology
Issue number5
DOIs
Publication statusPublished - 13-Feb-2020

Keywords

  • POSITIVE BLOOD CULTURES
  • ANTIBIOTIC-RESISTANCE
  • MYCOBACTERIUM-TUBERCULOSIS
  • CLINICAL MICROBIOLOGY
  • DIARRHEAL DISEASE
  • IDENTIFICATION
  • PCR
  • DIAGNOSTICS
  • ASSAY
  • TOOL

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