Innovative multicomponent reactions and their use in medicinal chemistry

Tryfon Zarganes Tzitzikas

Innovative multicomponent reactions and their use in medicinal chemistry

Tryfon Zarganes Tzitzikas

Drug Design

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

Aim of this dissertation is to address how innovative MCRs are in medicinal chemistry and how they can be used in different cases. The MCR derived products can be considered as a synthetic hub to a vast diversity of novel cyclic or acyclic scaffolds by employing different secondary transformations.
This “union of MCRs“ can serve as a strategy for the rational design of novel MCRs combining two (or more) different types of MCRs in a one-pot process.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Dömling, Alex, Supervisor Elsinga, Philip, Supervisor
Award date	20-Mar-2017
Place of Publication	[Groningen]
Publisher	University of Groningen
Print ISBNs	978-90-367-9675-0
Electronic ISBNs	978-90-367-9674-3
Publication status	Published - 2017

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Title and contents Final publisher's version, 652 KB
Chapter 1 Final publisher's version, 2.96 MB
Chapter 2 Final publisher's version, 2.26 MB
Chapter 3 Final publisher's version, 6.33 MB
Chapter 4 Final publisher's version, 1.88 MB
Chapter 5 Final publisher's version, 2.38 MB
Chapter 6 Final publisher's version, 2.84 MB
Chapter 7 Final publisher's version, 979 KB
Chapter 8 Final publisher's version, 1.3 MB
Chapter 9 Final publisher's version, 1.15 MB
Summary and future perspectives Final publisher's version, 544 KB
Samenvatting en toekomstperspectievenFinal publisher's version, 556 KB
Appendix Final publisher's version, 152 KB
Complete thesisFinal publisher's version, 22.1 MB
PropositionsFinal publisher's version, 102 KB

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title = "Innovative multicomponent reactions and their use in medicinal chemistry",

abstract = "Aim of this dissertation is to address how innovative MCRs are in medicinal chemistry and how they can be used in different cases. The MCR derived products can be considered as a synthetic hub to a vast diversity of novel cyclic or acyclic scaffolds by employing different secondary transformations. This “union of MCRs“ can serve as a strategy for the rational design of novel MCRs combining two (or more) different types of MCRs in a one-pot process.",

author = "{Zarganes Tzitzikas}, Tryfon",

year = "2017",

language = "English",

isbn = "978-90-367-9675-0",

publisher = "University of Groningen",

school = "University of Groningen",

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TY - BOOK

T1 - Innovative multicomponent reactions and their use in medicinal chemistry

AU - Zarganes Tzitzikas, Tryfon

PY - 2017

Y1 - 2017

N2 - Aim of this dissertation is to address how innovative MCRs are in medicinal chemistry and how they can be used in different cases. The MCR derived products can be considered as a synthetic hub to a vast diversity of novel cyclic or acyclic scaffolds by employing different secondary transformations. This “union of MCRs“ can serve as a strategy for the rational design of novel MCRs combining two (or more) different types of MCRs in a one-pot process.

AB - Aim of this dissertation is to address how innovative MCRs are in medicinal chemistry and how they can be used in different cases. The MCR derived products can be considered as a synthetic hub to a vast diversity of novel cyclic or acyclic scaffolds by employing different secondary transformations. This “union of MCRs“ can serve as a strategy for the rational design of novel MCRs combining two (or more) different types of MCRs in a one-pot process.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-9675-0

PB - University of Groningen

CY - [Groningen]

ER -

Innovative multicomponent reactions and their use in medicinal chemistry

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