Insights from the supplementary motor area syndrome in balancing movement initiation and inhibition

A. R. E. Potgieser*, BM de Jong, M. Wagemakers, E. W. Hoving, R. J. M. Groen

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    The supplementary motor area (SMA) syndrome is a characteristic neurosurgical syndrome that can occur after unilateral resection of the SMA. Clinical symptoms may vary from none to a global akinesia, predominantly on the contralateral side, with preserved muscle strength and mutism. A remarkable feature is that these symptoms completely resolve within weeks to months, leaving only a disturbance in alternating bimanual movements. In this review we give an overview of the old and new insights from the SMA syndrome and extrapolate these findings to seemingly unrelated diseases and symptoms such as Parkinson's disease (PD) and tics. Furthermore, we integrate findings from lesion, stimulation and functional imaging studies to provide insight in the motor function of the SMA.

    Original languageEnglish
    Article number960
    Number of pages11
    JournalFrontiers in Human Neuroscience
    Volume8
    DOIs
    Publication statusPublished - 28-Nov-2014

    Keywords

    • supplementary motor area (SMA)
    • supplementary motor area syndrome
    • akinetic mutism
    • neurosurgery
    • Parkinson's disease
    • tic disorders
    • TRANSCRANIAL MAGNETIC STIMULATION
    • MEDIAL FRONTAL-CORTEX
    • LA-TOURETTE-SYNDROME
    • CONTRASTING NEURONAL-ACTIVITY
    • ARTERY TERRITORY INFARCTION
    • ADJACENT CINGULATE CORTEX
    • PARKINSONS-DISEASE
    • BIMANUAL COORDINATION
    • MACAQUE MONKEY
    • ALIEN HAND

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