Instructable Nanoparticles Using Dynamic Combinatorial Chemistry

Yang Han; Piotr Nowak; Mathieu Colomb-Delsuc; Manuel Pernia Leal; Sijbren Otto

doi:10.1021/acs.langmuir.5b03673

Instructable Nanoparticles Using Dynamic Combinatorial Chemistry

Yang Han
, Piotr Nowak
, Mathieu Colomb-Delsuc
, Manuel Pernia Leal
, Sijbren Otto

Research output: Contribution to journal › Article › Academic › peer-review

21 Citations (Scopus)

102 Downloads (Pure)

Abstract

The application of nanoparticles to the multivalent recognition of biomacromolecules or programmed self-assembly requires control over the relative placement of chemical groups on their surface. We have developed a method to direct the functionalization of surfaces of aldehyde-equipped gold nanoparticles using a DNA template. An error-correction mechanism is built into the functionalization process thanks to the thermodynamic control enabled by the hydrazone exchange reaction. This reversible reaction can be conveniently switched off by removing the catalyst, preserving the functionalization.

Original language	English
Pages (from-to)	12658-12663
Number of pages	6
Journal	Langmuir
Volume	31
Issue number	46
DOIs	https://doi.org/10.1021/acs.langmuir.5b03673
Publication status	Published - 24-Nov-2015

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Instructable Nanoparticles Using Dynamic Combinatorial ChemistryFinal publisher's version, 1.74 MBLicence: Taverne

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abstract = "The application of nanoparticles to the multivalent recognition of biomacromolecules or programmed self-assembly requires control over the relative placement of chemical groups on their surface. We have developed a method to direct the functionalization of surfaces of aldehyde-equipped gold nanoparticles using a DNA template. An error-correction mechanism is built into the functionalization process thanks to the thermodynamic control enabled by the hydrazone exchange reaction. This reversible reaction can be conveniently switched off by removing the catalyst, preserving the functionalization.",

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Instructable Nanoparticles Using Dynamic Combinatorial Chemistry

Abstract

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