Insulin-like growth factor-I, cognition and brain aging

P Sytze van Dam*, André Aleman

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

109 Citations (Scopus)


Aging is associated with a decline in the activity of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis. As aging also coincides with a decline in specific cognitive functions and as some of these dysfunctions are also observed in subjects with GH deficiency, it has been hypothesised that a causal relationship exists between the reduction in circulating GH and/or IGF-I and the observed cognitive deficits in the elderly. The present review summarises the available data concerning the possible relation between GH, IGF-I and cognitive performance, and regarding possible underlying pathophysiological mechanisms.

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalEuropean Journal of Pharmacology
Issue number1-3
Publication statusPublished - 19-Apr-2004
Externally publishedYes


  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Brain/physiology
  • Cognition/physiology
  • Human Growth Hormone/metabolism
  • Humans
  • Insulin-Like Growth Factor I/metabolism
  • Middle Aged

Cite this