Insulin-like growth factor-I fails to reverse corticosteroid-induced protein catabolism in growing piglets

G Hellstern, DJ Reijngoud, F Stellaard, A Okken

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Corticosteroids such as dexamethasone (DEX) increase leucine turnover and oxidation in humans and animals, indicating whole body protein catabolism. Recently, interest has been growing in the use of recombinant polypeptides such as GH and IGF-I in reversing various states of catabolism. The aim of our study was to investigate whether IGF-I reverses corticosteroid-induced protein catabolism in rapidly growing piglets. Also, we wanted to determine whether IGF-I attenuates corticosteroid-induced hyperglycemia. To study these question, we performed leucine kinetics studies and measured blood glucose in eight piglets under postabsorptive conditions. We did three studies in each piglet: baseline, DEX treatment (5 mg/kg/d for 4 d), and DEX plus IGF-I treatment (25 mu g/kg/h for 6 h). DEX increased leucine turnover by 18 +/- 14% (mean +/- SD, p

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalPediatric Research
Volume39
Issue number3
Publication statusPublished - Mar-1996

Keywords

  • DEXAMETHASONE-TREATED RATS
  • HORMONE PREVENTS
  • IGF-I
  • GLUCOSE
  • BINDING
  • HUMANS
  • INFUSION
  • LEUCINE
  • SITES
  • SOMATOMEDIN

Fingerprint

Dive into the research topics of 'Insulin-like growth factor-I fails to reverse corticosteroid-induced protein catabolism in growing piglets'. Together they form a unique fingerprint.

Cite this