Insulin-like growth factor system in serum and cerebrospinal fluid in patients with multiple sclerosis

N Wilczak, M Schaaf, R Bredewold, C Streefland, A Teelken, J De Keyser*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    21 Citations (Scopus)

    Abstract

    The insulin-like growth factor (IGF) system influences oligodendrocyte survival, myelination, and immune functions. We examined whether alterations in the circulating IGF system occur in multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. We measured concentrations of IGF-I, IGF-II, and insulin-like growth factor binding proteins -1, -2, and -3 in both serum and cerebrospinal fluid from MS patients and age- and sex-matched controls. IGFBP-1 was not detectable in cerebrospinal fluid. We found no significant differences in any of the other components between patients with MS and controls. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)168-170
    Number of pages3
    JournalNeuroscience Letters
    Volume257
    Issue number3
    Publication statusPublished - 4-Dec-1998

    Keywords

    • multiple sclerosis
    • insulin-like growth factors
    • IGF-I
    • IGF-II
    • insulin-like growth factor binding proteins
    • cerebrospinal fluid
    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • IGF BINDING PROTEIN-1
    • FACTOR-I
    • TRANSGENIC MICE
    • OLIGODENDROCYTE DEVELOPMENT
    • B-CELL
    • T-CELL
    • MYELINATION
    • SECRETION

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