Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1

Corry-Anke Brandsma*, Victor Guryev, Wim Timens, Ana Ciconelle, Dirkje S Postma, Rainer Bischoff, Maria Johansson, Ekaterina S Ovchinnikova, Johan Malm, Gyorgy Marko-Varga, Thomas E Fehniger, Maarten van den Berge, Peter Horvatovich

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalThorax
Volume75
Issue number2
Early online date27-Jan-2020
DOIs
Publication statusPublished - Feb-2020

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