Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of a Nonrandomized Prospective Study Using a Standardized Follow-Up Program

Marije R. Vergeer*, Patricia A. H. Doornaert, Derek H. F. Rietveld, C. Rene Leemans, Ben J. Slotman, Johannes A. Langendijk

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

236 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to compare intensity-modulated radiation therapy (IMRT) and three-dimensional conventional radiotherapy (3D-CRT) with regard to patient-rated xerostomia, Radiation Therapy Oncology G roup (RTOG) acute and late xerostomia and health-related quality of life (HRQoL) among patients with head and neck squamous cell carcinoma (HNSCC).

Methods and Materials: Included were 241 patients with HNSCC treated with bilateral irradiation +/- chemotherapy. Since 2000, all patients treated with HNSCC were included in a program, which prospectively assessed acute and late morbidity according to the RTOG and HRQoL on a routine basis at regular intervals. Before October 2004, all patients were treated with 3D-CRT (N = 150). After clinical implementation in October 2004, 91 patients received IMRT. In this study, the differences regarding RTOG toxicity, xerostomia, and other items of HRQoL were analyzed.

Results: The use of IMRT resulted in a significant reduction of the mean dose of the parotid glands (27 Gy vs. 43 Gy (p

Conclusions: IMRT results in a significant reduction of patient- and observer-rated xerostomia, as well as other head and neck symptoms, compared with standard 3D-CRT. These differences translate into a significant improvement of the more general dimensions of HRQoL. (C) 2009 Elsevier Inc.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume74
Issue number1
DOIs
Publication statusPublished - 1-May-2009
Event49th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology (ASTRO) - , Canada
Duration: 27-Oct-20071-Nov-2007

Keywords

  • IMRT
  • Xerostomia
  • Quality of life
  • NECK-CANCER PATIENTS
  • CONVENTIONAL RADIOTHERAPY
  • NASOPHARYNGEAL CARCINOMA
  • OROPHARYNGEAL CARCINOMA
  • SALIVARY-GLANDS
  • INITIAL REPORT
  • HEAD
  • XEROSTOMIA
  • IRRADIATION
  • THERAPY

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