Interaction between drugs and the gut microbiome

Rinse K Weersma*, Alexandra Zhernakova, Jingyuan Fu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)
95 Downloads (Pure)

Abstract

The human gut microbiome is a complex ecosystem that can mediate the interaction of the human host with their environment. The interaction between gut microbes and commonly used non-antibiotic drugs is complex and bidirectional: gut microbiome composition can be influenced by drugs, but, vice versa, the gut microbiome can also influence an individual's response to a drug by enzymatically transforming the drug's structure and altering its bioavailability, bioactivity or toxicity (pharmacomicrobiomics). The gut microbiome can also indirectly impact an individual's response to immunotherapy in cancer treatment. In this review we discuss the bidirectional interactions between microbes and drugs, describe the changes in gut microbiota induced by commonly used non-antibiotic drugs, and their potential clinical consequences and summarise how the microbiome impacts drug effectiveness and its role in immunotherapy. Understanding how the microbiome metabolises drugs and reduces treatment efficacy will unlock the possibility of modulating the gut microbiome to improve treatment.

Original languageEnglish
Pages (from-to)1510-1519
Number of pages10
JournalGut
Volume69
Issue number8
Early online date14-May-2020
DOIs
Publication statusPublished - Aug-2020

Keywords

  • PROTON PUMP INHIBITORS
  • MULTI-OMICS
  • EFFICACY
  • COLONIZATION
  • INDIVIDUALS
  • REACTIVITY
  • INFECTION
  • PATTERNS
  • ALTER

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