Interferon Analogs

Klaas Poelstra; Jai Prakash; Leonie Beljaars; Ruchi Bansal

Interferon Analogs

Klaas Poelstra (Inventor), Jai Prakash (Inventor), Leonie Beljaars (Inventor), Ruchi Bansal (Inventor)

Research output: Patent

Abstract

The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

Original language	English
Patent number	20130064791
IPC	20130064791
Priority date	30/12/2010
Publication status	Published - 30-Dec-2010

Keywords

interferon gamma

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title = "Interferon Analogs",

abstract = "The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.",

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AU - Poelstra, Klaas

AU - Prakash, Jai

AU - Beljaars, Leonie

AU - Bansal, Ruchi

PY - 2010/12/30

Y1 - 2010/12/30

N2 - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

AB - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

KW - interferon gamma

M3 - Patent

M1 - 20130064791

ER -

Interferon Analogs

Abstract

Keywords

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