Interleukin-6 in relation to other proinflammatory cytokines, chemotactic activity and neutrophil activation in rheumatoid synovial fluid

MA VANLEEUWEN*, J WESTRA, PC LIMBURG, PLCM VANRIEL, MH VANRIJSWIJK

*Corresponding author for this work

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    Abstract

    Objective-To evaluate the relation between synovial fluid (SF) concentrations of interleukin-6 (IL-6) and other mediators of inflammation which are responsible for joint degradation in rheumatoid arthritis (RA).

    Methods-We measured IL-6, IL-1 beta, tumour necrosis factor alpha (TNF alpha), granulocyte macrophage colony stimulating factor, IL-8, and polymorphonuclear leucocyte (PMNL) chemotaxis and degranulation in SF from patients with RA (n = 30) in the early phase of the disease.

    Results-In a cross-sectional study IL-6 concentrations correlated with those of IL-1 beta, IL-8 and with PMNL activation as reflected by lactoferrin concentrations. In a longitudinal study, changes in IL-6 concentrations correlated with changes in TNF alpha, IL-8 and lactoferrin concentrations.

    Conclusion-IL-6 in SF appears to reflect the local proinflammatory, potentially erosive activity in RA. This supports the use of acute phase proteins, which are mainly induced by IL-6, as variables to monitor the course of RA.

    Original languageEnglish
    Pages (from-to)33-38
    Number of pages6
    JournalAnnals of the Rheumatic Diseases
    Volume54
    Issue number1
    DOIs
    Publication statusPublished - Jan-1995

    Keywords

    • TUMOR-NECROSIS-FACTOR
    • COLONY-STIMULATING FACTOR
    • BIOLOGICAL-FLUIDS
    • DISEASE-ACTIVITY
    • ARTHRITIS
    • SERUM
    • MACROPHAGE
    • PROTEIN
    • TISSUE
    • INFLAMMATION

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