Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

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Abstract

Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.

Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.

Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.

Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights

Original languageEnglish
Pages (from-to)1351-1357
Number of pages7
JournalClinical Neurophysiology
Volume130
Issue number8
Early online date2019
DOIs
Publication statusPublished - Aug-2019

Keywords

  • Dystonia
  • Deep brain stimulation
  • Biomarker
  • Intermuscular coherence
  • INTERNAL GLOBUS-PALLIDUS
  • LOCAL-FIELD POTENTIALS
  • PARKINSONS-DISEASE
  • MUSCLE-ACTIVITY
  • EMG COHERENCE
  • MOVEMENT
  • OSCILLATIONS
  • SYNCHRONIZATION
  • CONNECTIVITY
  • PATTERNS

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