International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation

bronchoalveolar lavage standardization workgroup, Tereza Martinu*, Angela Koutsokera, Christian Benden, Edward Cantu, Daniel Chambers, Marcelo Cypel, Jeffrey Edelman, Amir Emtiazjoo, Andrew J. Fisher, John Greenland, Don Hayes, David Hwang, Brian C. Keller, Erika D. Lease, Michael Perch, Masaaki Sato, Jamie L. Todd, Stijn Verleden, Jan von der ThüsenS. Samuel Weigt, Shaf Keshavjee

*Corresponding author for this work

    Research output: Contribution to journalEditorialAcademicpeer-review

    54 Citations (Scopus)

    Abstract

    Bronchoalveolar lavage (BAL) is a key clinical and research tool in lung transplantation (LTx). However, BAL collection and processing are not standardized across LTx centers. This International Society for Heart and Lung Transplantation–supported consensus document on BAL standardization aims to clarify definitions and propose common approaches to improve clinical and research practice standards. The following 9 areas are covered: (1) bronchoscopy procedure and BAL collection, (2) sample handling, (3) sample processing for microbiology, (4) cytology, (5) research, (6) microbiome, (7) sample inventory/tracking, (8) donor bronchoscopy, and (9) pediatric considerations. This consensus document aims to harmonize clinical and research practices for BAL collection and processing in LTx. The overarching goal is to enhance standardization and multicenter collaboration within the international LTx community and enable improvement and development of new BAL-based diagnostics.

    Original languageEnglish
    Pages (from-to)1171-1190
    Number of pages20
    JournalJournal of Heart and Lung Transplantation
    Volume39
    Issue number11
    DOIs
    Publication statusPublished - Nov-2020

    Keywords

    • bronchial wash
    • bronchoalveolar lavage
    • donor bronchoscopy
    • lung transplantation
    • methodology
    • pediatric bronchoscopy
    • standardization

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