Interrogating mitochondrial and metabolic involvement in Alzheimer’s disease: a focus on tissue analysis, in vitro platforms and mitochondrial calcium

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    Abstract

    Alzheimer’s Disease (AD) is a condition that affects the brain, leading to memory loss and other problems as people age. In AD, clumps of a protein called amyloid build up in the brain, damaging brain cells and causing them to die. The brain is made up of different types of cells, including neurons (which send electrical signals and help us think), microglia (the brain’s immune cells), and cells that support neurons (astrocytes, oligodendrocytes, also called glial cells). Historically, most research on AD focused on neurons because they can be directly affected by the buildup of amyloid protein and die. However, recent studies suggest that focusing only on amyloid might not be the best way to treat AD. Recently, and thanks to genetic studies, more attention has been given to microglial and glial cells. Since AD is closely linked to aging, scientists are now looking more at factors related to aging, such as changes in how cells get their energy. This thesis explores the role of mitochondria, which are the “powerhouses” of cells (in charge of providing energy to the cells), in AD by studying tissues from patients and animal models, as well as cells grown in the lab.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Boddeke, Erik, Supervisor
    • Dolga, Amalia, Supervisor
    Award date4-Dec-2024
    Place of Publication[Groningen]
    Publisher
    DOIs
    Publication statusPublished - 2024

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