Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study

F. H. Heida; J. B. F. Hulscher; M. Schurink; A. Timmer; E. M. W. Kooi; A. F. Bos; J. L. M. Bruggink; D. C. Kasper; M. Pones; T. Benkoe

doi:10.1016/j.jpedsurg.2014.11.037

Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study

F. H. Heida^*, J. B. F. Hulscher, M. Schurink, A. Timmer, E. M. W. Kooi, A. F. Bos, J. L. M. Bruggink, D. C. Kasper, M. Pones, T. Benkoe

^*Corresponding author for this work

Reproductive Origins of Adult Health and Disease (ROAHD)

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Abstract

Background: Intestinal fatty acid-binding protein (I-FABP) is considered as a specific marker for enterocyte damage in necrotizing enterocolitis (NEC).

Objective: The purpose of this study was to evaluate the association of plasma and urinary I-FABP levels with the extent of macroscopic intestinal necrosis in surgical NEC.

Methods: We combined data from prospective trials from two large academic pediatric surgical centers. Nine and 10 infants with surgical NEC were included, respectively. Plasma and urinary of I-FABP at disease onset were correlated with the length of intestinal resection during laparotomy.

Results: Median length of bowel resection was 10 cm (range 2.5-50) and 17 cm (range 0-51), respectively. Median I-FABP levels were 53 ng/mL (range 6.3-370) and 4.2 ng/mL (range 1.1-15.4) in plasma in cohort 1 respectively cohort 2 and 611 ng/mL (range 3-23,336) in urine. The length of bowel resection significantly correlated with I-FABP levels in plasma (Rho 0.68; p = 0.04 and Rho 0.66; p= 0.04) and in urine (Rho 0.92; p = 0.001).

Conclusion: This 'proof of concept' study demonstrates that plasma and urine I-FABP levels at disease onset was strongly associated with the length of intestinal resection in surgical NEC. This offers further evidence that I-FABP levels are a promising biomarker for assessing intestinal necrosis in infants with advanced NEC. (C) 2015 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1115-1118
Number of pages	4
Journal	Journal of Pediatric Surgery
Volume	50
Issue number	7
DOIs	https://doi.org/10.1016/j.jpedsurg.2014.11.037
Publication status	Published - Jul-2015

Keywords

Necrotizing enterocolitis
Necrosis
Surgical intervention
Pathology
Intestinal fatty acid-binding protein
EARLY-DIAGNOSIS
SEVERITY
MARKERS

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Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlateFinal publisher's version, 272 KBLicence: Taverne

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Heida, F. H., Hulscher, J. B. F., Schurink, M., Timmer, A., Kooi, E. M. W., Bos, A. F., Bruggink, J. L. M., Kasper, D. C., Pones, M., & Benkoe, T. (2015). Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study. Journal of Pediatric Surgery, 50(7), 1115-1118. https://doi.org/10.1016/j.jpedsurg.2014.11.037

@article{5d20bc58e5474d51afb104639029f5cb,

title = "Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study",

abstract = "Background: Intestinal fatty acid-binding protein (I-FABP) is considered as a specific marker for enterocyte damage in necrotizing enterocolitis (NEC).Objective: The purpose of this study was to evaluate the association of plasma and urinary I-FABP levels with the extent of macroscopic intestinal necrosis in surgical NEC.Methods: We combined data from prospective trials from two large academic pediatric surgical centers. Nine and 10 infants with surgical NEC were included, respectively. Plasma and urinary of I-FABP at disease onset were correlated with the length of intestinal resection during laparotomy.Results: Median length of bowel resection was 10 cm (range 2.5-50) and 17 cm (range 0-51), respectively. Median I-FABP levels were 53 ng/mL (range 6.3-370) and 4.2 ng/mL (range 1.1-15.4) in plasma in cohort 1 respectively cohort 2 and 611 ng/mL (range 3-23,336) in urine. The length of bowel resection significantly correlated with I-FABP levels in plasma (Rho 0.68; p = 0.04 and Rho 0.66; p= 0.04) and in urine (Rho 0.92; p = 0.001).Conclusion: This 'proof of concept' study demonstrates that plasma and urine I-FABP levels at disease onset was strongly associated with the length of intestinal resection in surgical NEC. This offers further evidence that I-FABP levels are a promising biomarker for assessing intestinal necrosis in infants with advanced NEC. (C) 2015 Elsevier Inc. All rights reserved.",

keywords = "Necrotizing enterocolitis, Necrosis, Surgical intervention, Pathology, Intestinal fatty acid-binding protein, EARLY-DIAGNOSIS, SEVERITY, MARKERS",

author = "Heida, {F. H.} and Hulscher, {J. B. F.} and M. Schurink and A. Timmer and Kooi, {E. M. W.} and Bos, {A. F.} and Bruggink, {J. L. M.} and Kasper, {D. C.} and M. Pones and T. Benkoe",

year = "2015",

month = jul,

doi = "10.1016/j.jpedsurg.2014.11.037",

language = "English",

volume = "50",

pages = "1115--1118",

journal = "Journal of Pediatric Surgery",

issn = "0022-3468",

publisher = "W B SAUNDERS CO-ELSEVIER INC",

number = "7",

}

Heida, FH, Hulscher, JBF, Schurink, M, Timmer, A , Kooi, EMW , Bos, AF , Bruggink, JLM, Kasper, DC, Pones, M & Benkoe, T 2015, 'Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study', Journal of Pediatric Surgery, vol. 50, no. 7, pp. 1115-1118. https://doi.org/10.1016/j.jpedsurg.2014.11.037

TY - JOUR

T1 - Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel

T2 - results from a multicenter study

AU - Heida, F. H.

AU - Hulscher, J. B. F.

AU - Schurink, M.

AU - Timmer, A.

AU - Kooi, E. M. W.

AU - Bos, A. F.

AU - Bruggink, J. L. M.

AU - Kasper, D. C.

AU - Pones, M.

AU - Benkoe, T.

PY - 2015/7

Y1 - 2015/7

N2 - Background: Intestinal fatty acid-binding protein (I-FABP) is considered as a specific marker for enterocyte damage in necrotizing enterocolitis (NEC).Objective: The purpose of this study was to evaluate the association of plasma and urinary I-FABP levels with the extent of macroscopic intestinal necrosis in surgical NEC.Methods: We combined data from prospective trials from two large academic pediatric surgical centers. Nine and 10 infants with surgical NEC were included, respectively. Plasma and urinary of I-FABP at disease onset were correlated with the length of intestinal resection during laparotomy.Results: Median length of bowel resection was 10 cm (range 2.5-50) and 17 cm (range 0-51), respectively. Median I-FABP levels were 53 ng/mL (range 6.3-370) and 4.2 ng/mL (range 1.1-15.4) in plasma in cohort 1 respectively cohort 2 and 611 ng/mL (range 3-23,336) in urine. The length of bowel resection significantly correlated with I-FABP levels in plasma (Rho 0.68; p = 0.04 and Rho 0.66; p= 0.04) and in urine (Rho 0.92; p = 0.001).Conclusion: This 'proof of concept' study demonstrates that plasma and urine I-FABP levels at disease onset was strongly associated with the length of intestinal resection in surgical NEC. This offers further evidence that I-FABP levels are a promising biomarker for assessing intestinal necrosis in infants with advanced NEC. (C) 2015 Elsevier Inc. All rights reserved.

AB - Background: Intestinal fatty acid-binding protein (I-FABP) is considered as a specific marker for enterocyte damage in necrotizing enterocolitis (NEC).Objective: The purpose of this study was to evaluate the association of plasma and urinary I-FABP levels with the extent of macroscopic intestinal necrosis in surgical NEC.Methods: We combined data from prospective trials from two large academic pediatric surgical centers. Nine and 10 infants with surgical NEC were included, respectively. Plasma and urinary of I-FABP at disease onset were correlated with the length of intestinal resection during laparotomy.Results: Median length of bowel resection was 10 cm (range 2.5-50) and 17 cm (range 0-51), respectively. Median I-FABP levels were 53 ng/mL (range 6.3-370) and 4.2 ng/mL (range 1.1-15.4) in plasma in cohort 1 respectively cohort 2 and 611 ng/mL (range 3-23,336) in urine. The length of bowel resection significantly correlated with I-FABP levels in plasma (Rho 0.68; p = 0.04 and Rho 0.66; p= 0.04) and in urine (Rho 0.92; p = 0.001).Conclusion: This 'proof of concept' study demonstrates that plasma and urine I-FABP levels at disease onset was strongly associated with the length of intestinal resection in surgical NEC. This offers further evidence that I-FABP levels are a promising biomarker for assessing intestinal necrosis in infants with advanced NEC. (C) 2015 Elsevier Inc. All rights reserved.

KW - Necrotizing enterocolitis

KW - Necrosis

KW - Surgical intervention

KW - Pathology

KW - Intestinal fatty acid-binding protein

KW - EARLY-DIAGNOSIS

KW - SEVERITY

KW - MARKERS

U2 - 10.1016/j.jpedsurg.2014.11.037

DO - 10.1016/j.jpedsurg.2014.11.037

M3 - Article

SN - 0022-3468

VL - 50

SP - 1115

EP - 1118

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

IS - 7

ER -

Intestinal fatty acid-binding protein levels in Necrotizing Enterocolitis correlate with extent of necrotic bowel: results from a multicenter study

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