INTESTINAL PERMEABILITY IN PATIENTS WITH CELIAC-DISEASE AND RELATIVES OF PATIENTS WITH CELIAC-DISEASE

RM VANELBURG*, JJ UIL, CJJ MULDER, HSA HEYMANS

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

150 Citations (Scopus)

Abstract

The functional integrity of the small bowel is impaired in coeliac disease. Intestinal permeability, as measured by the sugar absorption test probably reflects this phenomenon. In the sugar absorption test a solution of lactulose and mannitol was given to the fasting patient and the lactulose/mannitol ratio measured in urine collected over a period of five hours. The sugar absorption test was performed in nine patients with coeliac disease with an abnormal jejunum on histological examination, 10 relatives of patients with coeliac disease with aspecific symptoms but no villous atrophy, six patients with aspecific gastrointestinal symptoms but no villous atrophy, and 22 healthy controls to determine whether functional integrity is different in these groups. The lactulose/mannitol ratio (mean (SEM) is significantly higher in both coeliac disease (0.243 (0.034), p

Original languageEnglish
Pages (from-to)354-357
Number of pages4
JournalGut
Volume34
Issue number3
Publication statusPublished - Mar-1993

Keywords

  • GLUTEN-FREE DIET
  • CELIAC-DISEASE
  • SUGARS

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