Intestinal pseudo-obstruction as a complication of paragangliomas: Case report and literature review

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13 Citations (Scopus)

Abstract

Intestinal pseudo-obstruction is a rare and relatively unknown complication of phaeochromocytoma÷ paraganglioma (PCC÷PGL). Its pathophysiology can be explained by the hypersecretion of catecholamines, which may reduce the peristaltic activity of the gastrointestinal tract. Clinically, this can result in chronic constipation, intestinal pseudo-obstruction or even intestinal perforation. We conducted a comprehensive literature search and retrieved 34 cases of pseudo-obstruction caused by either benign or malignant PCC÷PGL. We also included a case from our centre that has not been described earlier. We conclude that intestinal pseudo-obstruction is a rare but potentially life-threatening complication of PCC÷PGL. Intravenous administration of phentolamine is the most frequently described treatment when surgical resection of the PCC÷PGL is not feasible.

Original languageEnglish
Pages (from-to)512-517
Number of pages6
JournalThe Netherlands Journal of Medicine
Volume71
Issue number10
Publication statusPublished - Dec-2013

Keywords

  • Intestinal pseudo-obstruction
  • paraganglioma
  • phaeochromocytoma
  • treatment
  • ACUTE COLONIC PSEUDOOBSTRUCTION
  • MALIGNANT PHEOCHROMOCYTOMA
  • PSEUDO-OBSTRUCTION
  • PARALYTIC ILEUS
  • ALPHA-METHYLTYROSINE
  • SEVERE CONSTIPATION
  • PRESENTING FEATURE
  • OGILVIES SYNDROME
  • PHAEOCHROMOCYTOMA
  • MANAGEMENT

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