Intracoronary infusion of mononuclear cells after PCI-treated myocardial infarction and arrhythmogenesis: is it safe?

L. F. H. J. Robbers, R. Nijveldt, A. M. Beek, M. J. B. Kemme, R. Delewi, Alexander Hirsch, A. M. van der Laan, P. A. van der Vleuten, J. J. Piek, F. Zijlstra, A. C. van Rossum*, HEBE Investigators

*Corresponding author for this work

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    Abstract

    To reduce long-term morbidity after revascularised acute myocardial infarction, different therapeutic strategies have been investigated. Cell therapy with mononuclear cells from bone marrow (BMMC) or peripheral blood (PBMC) has been proposed to attenuate the adverse processes of remodelling and subsequent heart failure. Previous trials have suggested that cell therapy may facilitate arrhythmogenesis. In the present substudy of the HEBE cell therapy trial, we investigated whether intracoronary cell therapy alters the prevalence of ventricular arrhythmias after 1 month or the rate of severe arrhythmogenic events (SAE) in the first year. In 164 patients of the trial we measured function and infarct size with cardiovascular magnetic resonance (CMR) imaging. Holter registration was performed after 1 month from which the number of triplets (3 successive PVCs) and ventricular tachycardias (VT, a parts per thousand yen4 successive PVCs) was assessed. Thirty-three patients (20%) showed triplets and/or VTs, with similar distribution amongst the groups (triplets: control n = 8 vs. BMMC n = 9, p = 1.00; vs. PBMC n = 10, p = 0.67. VT: control n = 9 vs. BMMC n = 9, p = 0.80; vs. PBMC n = 11, p = 0.69). SAE occurred in 2 patients in the PBMC group and 1 patient in the control group. In conclusion, intracoronary cell therapy is not associated with an increase in ventricular arrhythmias or SAE.

    Original languageEnglish
    Pages (from-to)133-137
    Number of pages5
    JournalNetherlands Heart Journal
    Volume20
    Issue number3
    DOIs
    Publication statusPublished - Mar-2012

    Keywords

    • Acute myocardial infarction
    • Cardiac arrhythmia
    • Cardiovascular magnetic resonance imaging
    • Severe arrhythmogenic events
    • Cell therapy
    • PERCUTANEOUS CORONARY INTERVENTION
    • SKELETAL MYOBLAST TRANSPLANTATION
    • BONE-MARROW
    • HEBE TRIAL
    • PROGENITOR CELLS
    • HEART-FAILURE
    • FOLLOW-UP
    • ISCHEMIA
    • THERAPY
    • DISEASE

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