INTRAOCULAR AND SERUM LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN ACUTE RETINAL NECROSIS AND OCULAR TOXOPLASMOSIS

Karin Wiertz*, Lenneke De Visser, Ger Rijkers, Jolanda De Groot-Mijnes, Leonie Los, Aniki Rothova

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Purpose: To determine the intraocular and serum vascular endothelial growth factor (VEGF) levels in patients with acute retinal necrosis (ARN) and compare those with VEGF levels found in patients with ocular toxoplasmosis (OT).

Methods: Paired intraocular fluid and serum samples of 17 patients with ARN and of 16 patients with OT were analyzed by ELISA for VEGF levels, and the clinical records were reviewed.

Results: The mean intraocular VEGF levels in patients with ARN were higher than in patients with OT (P = 0.005), whereas the serum levels did not differ. Intraocular VEGF levels exceeded the serum levels in 8 of 17 patients (47%) with ARN compared with 1 of 16 patients (6%) with OT (P = 0.009). The group with high intraocular VEGF was associated with a more extensive retinitis and lower visual acuity at 3-month follow-up (P <0.001 and P = 0.031, respectively).

Conclusion: Intraocular VEGF levels were elevated in patients with ARN compared with OT patients. Our results suggest strong intraocular VEGF production in ARN, which might be of importance for the treatment of these patients. RETINA 30:1734-1738, 2010

Original languageEnglish
Pages (from-to)1734-1738
Number of pages5
JournalRetina-The journal of retinal and vitreous diseases
Volume30
Issue number10
DOIs
Publication statusPublished - 2010

Keywords

  • acute retinal necrosis
  • intraocular VEGF levels
  • ocular toxoplasmosis
  • serum VEGF levels
  • vascular endothelial growth factor
  • PROLIFERATIVE DIABETIC-RETINOPATHY
  • MACULAR DEGENERATION
  • AQUEOUS-HUMOR
  • FACTOR VEGF
  • INTRAVITREAL BEVACIZUMAB
  • EDEMA
  • DISEASE
  • ASSOCIATION
  • MANAGEMENT

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