Abstract
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
Original language | English |
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Pages (from-to) | 1315-U202 |
Number of pages | 6 |
Journal | Nature Medicine |
Volume | 17 |
Issue number | 10 |
DOIs | |
Publication status | Published - 18-Sept-2011 |
Keywords
- BREAST-CANCER
- MANAGEMENT
- SURGERY
- EXPRESSION
- STRATEGIES
- SURVIVAL
- FUTURE
- TISSUE
- MODEL