Intraperitoneal chemotherapy in ovarian cancer

LS Hofstra, EGE de Vries, NH Mulder, PHB Willemse*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

From a theoretical viewpoint, intraperitoneal therapy (IP) in patients with ovarian cancer; a malignancy which remains mainly confined to the peritoneal cavity is logical. Over the past decades this approach has evolved into a therapeutic strategy for a selected group of patients. Data available at present suggest a beneficiary role ( For IP therapy) as first-line treatment in patients with small residual disease and possibly following initial reduction of tumor load by systemic chemotherapy. The theoretical basis, the present status of IP therapy in different settings, pharmacology, factors limiting its clinical utility and future directions are reviewed. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish
Pages (from-to)133-143
Number of pages11
JournalCANCER TREATMENT REVIEWS
Volume26
Issue number2
Publication statusPublished - Apr-2000

Keywords

  • ovarian cancer
  • intraperitoneal
  • chemotherapy
  • GYNECOLOGIC-ONCOLOGY-GROUP
  • PHASE-II TRIAL
  • 2ND-LOOK LAPAROTOMY
  • CARCINOMA PATIENTS
  • PERITONEAL-CAVITY
  • RESIDUAL DISEASE
  • PHARMACOKINETIC EVALUATION
  • INTRAVENOUS CISPLATIN
  • CYTOSINE-ARABINOSIDE
  • COMPLETE REMISSION

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